Solvent-Free Buchwald-Hartwig Reaction of Aryl and Heteroaryl Halides with Secondary Amines

被引：50
|
作者：
Topchiy, Maxim A. [1 ]
Asachenko, Andrey F. [1 ]
Nechaev, Mikhail S. [1 ,2 ]
机构：
[1] Russian Acad Sci, AV Topchiev Inst Petrochem Synth, Moscow 119991, Russia
[2] Moscow MV Lomonosov State Univ, Moscow 119991, Russia
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 16期
基金：
俄罗斯基础研究基金会;
关键词：
Palladium; Solvent-free reactions; Cross-coupling; Amination; PALLADIUM-CATALYZED AMINATION; COMPLEXES; NHC;
D O I：
10.1002/ejoc.201402077
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly efficient solvent-free protocol for the Buchwald-Hartwig amination of (hetero)aryl halides by secondary amines was developed. The reaction is mediated by a Pd(OAc)(2)/RuPhos catalytic system in air. Various (hetero) aryl halides were coupled with diaryl, alkyl-aryl, and dialkylamines in good to excellent yields (51 examples, 50-99% yield).
引用
收藏
页码：3319 / 3322
页数：4
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