Solvent-Free Buchwald-Hartwig Reaction of Aryl and Heteroaryl Halides with Secondary Amines

被引：50

作者：

Topchiy, Maxim A. ^{[1
]}

Asachenko, Andrey F. ^{[1
]}

Nechaev, Mikhail S. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, AV Topchiev Inst Petrochem Synth, Moscow 119991, Russia

[2] Moscow MV Lomonosov State Univ, Moscow 119991, Russia

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 16期

基金：

俄罗斯基础研究基金会;

关键词：

Palladium; Solvent-free reactions; Cross-coupling; Amination; PALLADIUM-CATALYZED AMINATION; COMPLEXES; NHC;

D O I：

10.1002/ejoc.201402077

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient solvent-free protocol for the Buchwald-Hartwig amination of (hetero)aryl halides by secondary amines was developed. The reaction is mediated by a Pd(OAc)(2)/RuPhos catalytic system in air. Various (hetero) aryl halides were coupled with diaryl, alkyl-aryl, and dialkylamines in good to excellent yields (51 examples, 50-99% yield).

引用

页码：3319 / 3322

页数：4

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