Targeting Transcription Factors in Cancer

被引:220
作者
Bhagwat, Anand S. [1 ]
Vakoc, Christopher R. [1 ]
机构
[1] Cold Spring Harbor Lab, 1 Bungtown Rd, Cold Spring Harbor, NY 11724 USA
来源
TRENDS IN CANCER | 2015年 / 1卷 / 01期
基金
美国国家卫生研究院;
关键词
D O I
10.1016/j.trecan.2015.07.001
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Transcription factors (TFs) are commonly deregulated in the pathogenesis of human cancer and are a major class of cancer cell dependencies. Consequently, targeting of TFs can be highly effective in treating particular malignancies, as highlighted by the clinical efficacy of agents that target nuclear hormone receptors. In this review we discuss recent advances in our understanding of TFs as drug targets in oncology, with an emphasis on the emerging chemical approaches to modulate TF function. The remarkable diversity and potency of TFs as drivers of cell transformation justifies a continued pursuit of TFs as therapeutic targets for drug discovery.
引用
收藏
页码:53 / 65
页数:13
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