Differential prenatal toxicity of branched phthalate esters in rats

被引：64

作者：

Hellwig, J ^{[1
]}

Freudenberger, H ^{[1
]}

Jackh, R ^{[1
]}

机构：

[1] BASF AG,DEPT TOXICOL,D-67056 LUDWIGSHAFEN,GERMANY

来源：

FOOD AND CHEMICAL TOXICOLOGY | 1997年 / 35卷 / 05期

关键词：

D O I：

10.1016/S0278-6915(97)00008-2

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Several phthalate esters with alcohol moieties ranging from C-5-C-10 chains were investigated for prenatal toxicity in 10 rats per group after gavage administration of 0, 40, 200 and 1000 mg/kg/day from gestation day 6 to 15. At 1000 mg/kg di(2-ethylhexyl) phthalate showed clear foetotoxicity, embryolethality and teratogenicity. No significant effects were recorded at 40 and 200 mg/kg. Di-711-phthalate, a phthalic ester with linear components and a predominantly oc-methyl branching type, and di-isopentylphthalate showed a very similar spectrum of effects. Interestingly, the alcohol moiety of di-711-phthalate, 711-alcohol was developmentally inactive in a previous experiment. Di-iso-decylphthalate and three types of di-iso-nonylphthalate showed foetal effects of borderline significance at 1000 mg/kg/day. (C) 1997 Elsevier Science Ltd.

引用

页码：501 / 512

页数：12

共 31 条

[1] A RAPID METHOD FOR DETECTING MALFORMATIONS IN RAT FETUSES [J].