Enzymatic desymmetrization/resolution of epoxydiols derived from 1,4-naphthoquinone, 5-hydroxy-1,4-naphthoquinone and 5,8-dihydroxy-1,4-naphthoquinone

被引：12

作者：

Betts, RL ^{[1
]}

Murphy, ST ^{[1
]}

Johnson, CR ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

来源：

TETRAHEDRON-ASYMMETRY | 2004年 / 15卷 / 18期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/j.tetasy.2004.07.051

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The enzymatic desymmetrization/resolution of epoxydiols generated from the basic epoxidation and reduction of 1,4-naphthoquoinone, 5-hydroxy-1,4-naphthoquinone and 5,8-dihydroxy-1,4-naphthoquinone is described. 2,3-Epoxy-1(alpha),2(alpha),3(alpha),4(alpha)-tetrahydronaphthalene-1,4-diol and 5,8-diallyloxy-2,3-epoxy-1(alpha),2(alpha),3(alpha),4(alpha)-tetrahydronaphthalene-1,4-diol were desymmetrized in the presence of isopropenyl acetate using Burholderia cepacia lipase and Candida antartica lipase B, respectively. An enzymatic resolution of 8-benzyloxy-2,3-epoxy-1(alpha),2(alpha),3(alpha),4(alpha)-tetrahydronaphthalene-1,4-diol using B. cepacia lipase in isopropenyl acetate is also described. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2853 / 2860

页数：8

共 34 条

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