Treatment of peripheral sensorineural hearing loss: gene therapy

被引：24
作者：
Duan, M
Venail, F
Spencer, N
Mezzina, M
机构：
[1] Karolinska Hosp, Ctr Hearing & Commun Res, SE-17176 Stockholm, Sweden
[2] Karolinska Hosp, Dept Clin Neurosci, SE-17176 Stockholm, Sweden
[3] Karolinska Hosp, Dept Otolaryngol, S-10401 Stockholm, Sweden
[4] Anhui Med Univ, Dept Otolaryngol, Hefei, Peoples R China
[5] CHU Gui de Chauliac, ENT Dept, Montpellier, France
[6] Genethon, CNRS, UMR 8115, Evry, France
来源：
GENE THERAPY | 2004年 / 11卷 / Suppl 1期
关键词：
inner ear; spiral ganglion cell; hair cell; adenovirus; adeno-associated virus; lentivirus; neurotrophin; antioxidant; stem cell;
D O I：
10.1038/sj.gt.3302369
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Noise, chemicals and genetic defects are all common causes of irreversible hearing loss, which at present have no cure. Gene therapy may soon be utilized in both the protection and the treatment of these exogenous and endogenous sources of hearing loss. Gene therapy technology is rapidly developing and the inner ear is a particularly feasible model for gene therapy. This review outlines our current understanding of the mechanisms behind deafness and prospects for treatment, discusses the inner ear model in detail and reviews the efforts that have been made in inner ear gene therapy. Finally, the proposed next steps will be discussed. The viral mediated delivery of neurotrophins and antoxidants offers imminent promise in preventing and treating exogenous hearing loss and improving cochlear implant therapy.
引用
收藏
页码：S51 / S56
页数：6
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