An efficient genetic screen in Drosophila to identify nuclear-encoded genes with mitochondrial function

被引：24
|
作者：
Liao, T. S. Vivian
Call, Gerald B.
Guptan, Preeta
Cespedes, Albert
Marshall, Jamie
Yackle, Kevin
Owusu-Ansah, Edward
Mandal, Sudip
Fang, Q. Angela
Goodstein, Gelsey L.
Kim, William
Banerjee, Utpal
机构：
[1] Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Dept Biol Chem, Los Angeles, CA 90095 USA
来源：
GENETICS | 2006年 / 174卷 / 01期
关键词：
D O I：
10.1534/genetics.106.061705
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We conducted a screen for glossy-eye flies that fail to incorporate BrdU in the third larval instar eye disc but exhibit normal neuronal differentiation and isolated 23 complementation groups of mutants. These same phenotypes were previously seen in mutants for cytochrome c oxidase subunit Va. We have molecularly characterized six complementation groups and, surprisingly, each encodes a mitochondrial protein. Therefore, we believe our screen to be an efficient method for identifying genes with mitochondrial function.
引用
收藏
页码：525 / 533
页数：9
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