The Advancement of Long Non-Coding RNAs in Cholangiocarcinoma Development

被引:19
作者
Jiang, Fengru [1 ]
Ling, Xiaofeng [1 ]
机构
[1] Peking Univ, Hosp 3, Dept Gen Surg, 49 North Garden Rd, Beijing 100191, Peoples R China
来源
JOURNAL OF CANCER | 2019年 / 10卷 / 11期
关键词
cholangiocarcinoma; lncRNA; proliferation; invasion; prognosis; PROMOTES CELL-PROLIFERATION; EXERTS ONCOGENIC PROPERTIES; INTRAHEPATIC CHOLANGIOCARCINOMA; POOR-PROGNOSIS; MESSENGER-RNA; TUMOR-GROWTH; EXPRESSION; INVASION; MIGRATION; TRENDS;
D O I
10.7150/jca.32411
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cholangiocarcinoma (CCA) is a malignancy with increasing incidence in recent years. CCA patients are usually diagnosed at advanced stage due to lack of apparent symptoms and specifically diagnostic markers. Nowadays, surgical removal is the only effective method for CCA whereas overall 5-year-survival rate keeps around 10%. Long-noncoding RNA (lncRNA), a subtype of noncoding RNA, is widely studied to be abnormally expressed in multiple cancers including CCA. LncRNA can promote proliferation, migration, invasion and inhibit apoptosis of CCA. Moreover, lncRNA is negatively correlated with the prognosis of CCA. LncRNA may contribute to the development of CCA via modulating gene transcription, sponging microRNA, regulating CCA-related signaling pathways or protein expression. LncRNA is thought to be potential diagnostic markers and therapeutic targets for CCA.
引用
收藏
页码:2407 / 2414
页数:8
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