Extrinsic regulators of epithelial tumor progression: metalloproteinases

被引：104

作者：

Bergers, G

Coussens, LM

机构：

[1] Univ Calif San Francisco, Hormone Res Inst, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Inst Canc Res, San Francisco, CA 94115 USA

[3] Univ Calif San Francisco, Dept Anat Patol, San Francisco, CA 94115 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2000年 / 10卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0959-437X(99)00043-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Extracellular metal-dependent proteinases regulate cell behavior by remodeling stromal and cell surface proteins, thereby influencing cell recruitment, cell shape, motility, proliferation, survival, genomic (in)stability, and differentiation. In recent years, the importance of proteinase-induced signaling has been underscored by evidence that altered regulation of cell-extracellular matrix and cell-cell interactions by proteinases can contribute, in a causal manner, to neoplastic progression.

引用

页码：120 / 127

页数：8

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