Distinct spatiotemporal pattern of CNS lesions revealed by USPIO-enhanced MRI in MOG-induced EAE rats implicates the involvement of spino-olivocerebellar pathways

被引：24

作者：

Chin, Chih-Liang ^{[1
]}

Pai, Madhavi ^{[4
]}

Bousquet, Peter F. ^{[2
]}

Schwartz, Annette J. ^{[3
]}

O'Connor, Elizabeth M. ^{[3
]}

Nelson, Christine M. ^{[2
]}

Hradil, Vincent P. ^{[4
]}

Cox, Bryan F.

McRae, Bradford L. ^{[2
]}

Fox, Gerard B.

机构：

[1] Abbott Labs, GPRD, Expt Imaging, Adv Technol, Abbott Pk, IL 60064 USA

[2] Abbott Biores Ctr, Dept Pharmacol, Worcester, MA 01605 USA

[3] Abbott Biores Ctr, Dept Pathol, Worcester, MA 01605 USA

[4] Abbott Labs, GPRD, Neurosci Res, Abbott Pk, IL 60064 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 211卷 / 1-2期

关键词：

MS; EAE; MRI; Spino-olivocerebellar pathways; USPIO; Inferior olives; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; SUPERPARAMAGNETIC IRON-OXIDE; ANTIGEN-INDUCED ARTHRITIS; CENTRAL-NERVOUS-SYSTEM; MULTIPLE-SCLEROSIS; MACROPHAGE INFILTRATION; IN-VIVO; MEDICAL PROGRESS; QUANTITATIVE MRI;

D O I：

10.1016/j.jneuroim.2009.03.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

USPIO-enhanced MRI allows non-invasive visualization of mononuclear cell infiltration into CNS lesions in MS and EAE. Herein, we show a distinct spatiotemporal pattern of CNS lesions that reveals the involvement of spino-olivocerebellar pathways in MOG-induced EAE rats using USPIO-enhanced MRI. Specifically, lesions of the inferior olives were observed primarily in the acute phase whereas lesions of cerebellum or spinal cord/brainstem were observed during the relapse phase. Further, behavioral deficits observed from these animals are consistent with the functional role of spino-olivocerebellar pathways in coordination and movement. Collectively, our results provide new insights into the pathophysiology of this animal model of MS. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：49 / 55

页数：7

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