Quetiapine reduces nocturnal urinary cortisol excretion in healthy subjects

被引:38
作者
Cohrs, S [1 ]
Pohlmann, K [1 ]
Guan, ZH [1 ]
Jordan, W [1 ]
Meier, A [1 ]
Huether, G [1 ]
Rüther, E [1 ]
Rodenbeck, A [1 ]
机构
[1] Univ Gottingen, Dept Psychiat & Psychotherapy, D-37075 Gottingen, Germany
关键词
quetiapine; antipsychotic; urinary excretion; cortisol; melatonin; HPA-system;
D O I
10.1007/s00213-003-1766-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Rationale. Hypothalamic-pituitary-adrenal (HPA) axis dysfunction is a frequent finding in psychiatric disorders, including psychotic depression and schizophrenia. Conflicting results exist concerning the influence of antipsychotics on the HPA-axis. Objective. Therefore, this double-blind, placebo-controlled, randomized cross-over study investigated the effect of quetiapine on nocturnal urinary cortisol and melatonin excretion in 13 healthy male subjects under conditions of undisturbed and experimentally disturbed sleep. Methods. Volunteers were studied 3 times for 3 consecutive nights (N0, adaptation; N1, standard sleep conditions; N2, acoustic stress) 4 days apart. Placebo, quetiapine 25 mg or quetiapine 100 mg was administered orally 1 h before bedtime on nights 1 and 2. Urine produced during the 8-h bedtime period was collected for later determination of cortisol and melatonin concentrations by standard radioimmunoassays. Results. MANOVA showed a significant effect for N1 vs. N2 with elevated total amount of cortisol (p<0.005) and melatonin (p<0.05) excretion after acoustic stress. Both quetiapine 25 mg and 100 mg significantly (p<0.0005) reduced the total amount of cortisol excretion in comparison to placebo. No interaction effect of stress condition was observed. There was no effect of quetiapine on melatonin levels. Conclusion. The significant reduction of nocturnal cortisol excretion following quetiapine reflects a decreased activity of the HPA-axis in healthy subjects. This finding may be an important aspect in quetiapine's mode of action in different patient populations.
引用
收藏
页码:414 / 420
页数:7
相关论文
共 65 条
[1]  
Adityanjee, 2002, J CLIN PSYCHIAT, V63, P32
[2]   ADRENERGIC CONTROL OF THE SECRETION OF ANTERIOR-PITUITARY HORMONES [J].
ALDAMLUJI, S .
BAILLIERES CLINICAL ENDOCRINOLOGY AND METABOLISM, 1993, 7 (02) :355-392
[3]  
Allolio B, 1987, Horm Metab Res Suppl, V16, P36
[4]   EFFECT OF MECLASTINE, A SELECTIVE H-1 RECEPTOR ANTAGONIST, UPON ACTH RELEASE [J].
ALLOLIO, B ;
DEUSS, U ;
KAULEN, D ;
WINKELMANN, W .
CLINICAL ENDOCRINOLOGY, 1983, 19 (02) :239-245
[5]   HPA axis and cytokines dysregulation in schizophrenia: potential implications for the antipsychotic treatment [J].
Altamura, AC ;
Boin, F ;
Maes, M .
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 1999, 10 (01) :1-4
[6]   Effects of the antipsychotic drug sulpiride on reproductive hormones in healthy men: Relationship with body weight regulation [J].
Baptista, T ;
Alastre, T ;
Contreras, Q ;
Martinez, JL ;
de Baptista, EA ;
Paez, X ;
Hernandez, L .
PHARMACOPSYCHIATRY, 1997, 30 (06) :250-255
[7]   Effects of the antipsychotic drug sulpiride on reproductive hormones in healthy premenopausal women: Relationship with body weight regulation [J].
Baptista, T ;
Molina, MG ;
Martinez, JL ;
de Quijada, M ;
de Cuesta, IC ;
Acosta, A ;
Paez, X ;
Martinez, JM ;
Hernandez, L .
PHARMACOPSYCHIATRY, 1997, 30 (06) :256-262
[8]   EFFECTS OF ACUTE ADMINISTRATION OF ZETIDOLINE, A NEW ANTIDOPAMINERGIC DRUG, ON PLASMA PROLACTIN AND ALDOSTERONE LEVELS IN MAN [J].
BARBIERI, C ;
PARODI, M ;
BRUNO, S ;
BERTASSI, F ;
BENAGLIA, D ;
MOSER, P ;
MERONI, R ;
DUBINI, A .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1984, 26 (01) :29-32
[9]   MELATONIN IMMUNOREACTIVITY IN CEREBROSPINAL-FLUID OF SCHIZOPHRENIC-PATIENTS AND HEALTHY CONTROLS [J].
BECKMANN, H ;
WETTERBERG, L ;
GATTAZ, WF .
PSYCHIATRY RESEARCH, 1984, 11 (02) :107-110
[10]   Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorder [J].
Bilder, RM ;
Goldman, RS ;
Volavka, J ;
Czobor, P ;
Hoptman, M ;
Sheitman, B ;
Lindenmayer, JP ;
Citrome, L ;
McEvoy, J ;
Kunz, M ;
Chakos, M ;
Cooper, TB ;
Horowitz, TL ;
Lieberman, JA .
AMERICAN JOURNAL OF PSYCHIATRY, 2002, 159 (06) :1018-1028