Chemoprevention of lung carcinogenesis in addicted smokers and ex-smokers

被引：73

作者：

Hecht, Stephen S. ^{[1
]}

Kassie, Fekadu ^{[1
]}

Hatsukami, Dorothy K. ^{[1
]}

机构：

[1] Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN 55455 USA

来源：

NATURE REVIEWS CANCER | 2009年 / 9卷 / 07期

关键词：

CRUCIFEROUS VEGETABLE CONSUMPTION; TOBACCO-SPECIFIC CARCINOGEN; A/J MICE; CIGARETTE-SMOKE; GREEN TEA; PULMONARY CARCINOGENESIS; CHEMICAL CARCINOGENESIS; CANCER CHEMOPREVENTION; DNA METHYLATION; VINYL CARBAMATE;

D O I：

10.1038/nrc2674

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chemoprevention of lung carcinogenesis is one approach to controlling the epidemic of lung cancer caused by cigarette smoking. The target for chemoprevention should be the activities of the multiple carcinogens, toxicants, co-carcinogens, tumour promoters and inflammatory compounds in cigarette smoke. At present there are many agents, both synthetic and naturally occurring, that prevent lung tumour development in well-established animal models. It seems likely that logically constructed mixtures of these agents, developed from the ground up, will be necessary for the prevention of lung carcinogenesis.

引用

页码：476 / 488

页数：13

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