Synthesis and biological activity of some rigid analogues of flavone-8-acetic acid

被引：85

作者：

Valenti, P

Bisi, A

Rampa, A

Belluti, F

Gobbi, S

Zampiron, A

Carrara, M

机构：

[1] Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy

[2] Univ Padua, Dept Pharmacol, I-35131 Padua, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2000年 / 8卷 / 01期

关键词：

flavone-8-acetic acid; antitumour compounds; human colon adenocarcinoma; ovarian adenocarcinoma; macrophages; lytic properties;

D O I：

10.1016/S0968-0896(99)00282-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Some rigid analogues of flavone-8-acetic acid are described. Direct in vitro toxicity of the synthesised compounds was evaluated towards four tumoral cell lines and the ability of these compounds to stimulate mouse peritoneal macrophages in culture to become tumoricidal (indirect toxicity) was also studied. All compounds were able to induce direct cytotoxicity only at very high concentrations but showed a remarkable indirect activity. In particular compound 4d was able to significantly increase macrophage lyric properties and has been selected for further investigations. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：239 / 246

页数：8

共 53 条

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Aitken RA, 1998, ARCH PHARM, V331, P405

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