Intrahepatic bile duct injury and nodular regenerative hyperplasia of the liver in a patient with polyarteritis nodosa

被引:31
作者
Goritsas, CP
Repanti, M
Papadaki, E
Lazarou, N
Andonopoulos, AP
机构
[1] PATRAS REG UNIV HOSP,DEPT INTERNAL MED,PATRAS,GREECE
[2] AGIOS ANDREAS PATRAS GEN HOSP,DEPT PATHOL,PATRAS,GREECE
关键词
nodular regenerative hyperplasia of the liver; polyarteritis nodosa; sclerosing cholangitis;
D O I
10.1016/S0168-8278(97)80441-2
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Although involvement of the hepatic vasculature in patients with polyarteritis nodosa is not unusual, biliary manifestations are very rare. We describe a patient with polyarteritis nodosa presenting with a febrile cholestatic anicteric syndrome. Histological examination of the liver revealed necrotizing arteritis of small hepatic arteries associated with significant lesions of intrahepatic bile ducts of the sclerosing cholangitis type, i.e. fibrous collar around the ducts, periductal inflammation and ductal proliferation, Concomitant nodular regenerative hyperplasia was found, a condition which has rarely been described in association with polyarteritis nodosa, We think that hepatic arteritis compromising arterial blood flow to the liver was responsible for the most likely ischemic nature of the bile duct injury and the nodular plasia seen in our patient.
引用
收藏
页码:727 / 730
页数:4
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