A comparative gene map of the horse (Equus caballus)

被引：48

作者：

Caetano, AR

Shiue, YL

Lyons, LA

O'Brien, SJ

Laughlin, TF

Bowling, AT

Murray, JD ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Anim Sci, Livermore, CA 95616 USA

[2] Univ Calif Davis, Vet Genet Lab, Livermore, CA 95616 USA

[3] NCI, Frederick Canc Res & Dev Ctr, Lab Genom Divers, Frederick, MD 21702 USA

[4] E Tennessee State Univ, Dept Biol Sci, Johnson City, TN 37614 USA

[5] Univ Calif Davis, Dept Populat Hlth & Reprod, Livermore, CA 95616 USA

来源：

GENOME RESEARCH | 1999年 / 9卷 / 12期

关键词：

D O I：

10.1101/gr.9.12.1239

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A comparative gene map of the horse genome composed of 127 loci was assembled based on the new assignment of 68 equine type I loci and on data published previously. PCR primers based on consensus gene sequences conserved across mammalian species were used to amplify markers for assigning 68 equine type I loci to 27 horse synteny groups established previously with a horse-mouse somatic cell hybrid panel (SCHP, UC Davis). This increased the number of coding genes mapped to the horse genome by over 2-fold and allowed refinements of the comparative mapping data available For this species. In conjunction with 57 previous assignments of type I loci to the horse genome map, these data have allowed us to confirm the assignment of 24 equine synteny groups to their respective chromosomes, to provisionally assign nine synteny groups to chromosomes, and to further refine the genetic composition established with Zoo-FISH of two horse chromosomes. The equine type I markers developed in this study provide an important resource for the future development of the horse linkage and physical genome maps.

引用

页码：1239 / 1249

页数：11

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