Raney Ni catalyzed azide-alkyne cycloaddition reaction

被引：40

作者：

Rao, H. Surya Prakash ^{[1
]}

Chakibanda, Guravaiah ^{[1
]}

机构：

[1] Pondicherry Univ, Dept Chem, Pondicherry 605014, India

来源：

RSC ADVANCES | 2014年 / 4卷 / 86期

关键词：

TERMINAL ALKYNES; CLICK CHEMISTRY; LIGAND; 1,2,3-TRIAZOLES; MECHANISM;

D O I：

10.1039/c4ra07057g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Raney Ni efficiently catalyzes acetylene azide cycloaddition reactions to form 1,2,3-triazoles. Unlike the CuSO4/sodium ascorbate reagent system, there is no need for a reducing agent under Raney Ni catalysis. Terminal acetylene selectivity, 1,4-regioselectivity and mild reaction conditions are prominent features of the method. Mechanistic probing revealed that the reaction does not go through nickel acetylides.

引用

页码：46040 / 46048

页数：9

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