Immunologic strategies for HIV-1 remission and eradication

被引：173
作者：
Barouch, Dan H. [1 ,2 ,3 ]
Deeks, Steven G. [4 ]
机构：
[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Ctr Virol & Vaccine Res, Boston, MA 02215 USA
[2] MIT, Massachusetts Gen Hosp, Ragon Inst, Cambridge, MA 02139 USA
[3] Harvard Univ, Cambridge, MA 02139 USA
[4] Univ Calif San Francisco, San Francisco, CA 94110 USA
来源：
SCIENCE | 2014年 / 345卷 / 6193期
关键词：
CD4(+) T-CELLS; ACTIVE ANTIRETROVIRAL THERAPY; INTERFERON-STIMULATED GENES; PERSISTENT LCMV INFECTION; PLACEBO-CONTROLLED TRIAL; HIGHLY PATHOGENIC SIV; IN-VIVO; NEUTRALIZING ANTIBODIES; ANTIVIRAL THERAPY; RHESUS-MONKEYS;
D O I：
10.1126/science.1255512
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Antiretroviral therapy (ART) is able to suppress HIV-1 replication indefinitely in individuals who have access to these medications, are able to tolerate these drugs, and are motivated to take them daily for life. However, ART is not curative. HIV-1 persists indefinitely during ART as quiescent integrated DNA within memory CD4(+) T cells and perhaps other long-lived cellular reservoirs. In this Review, we discuss the role of the immune system in the establishment and maintenance of the latent HIV-1 reservoir. A detailed understanding of how the host immune system shapes the size and distribution of the viral reservoir should lead to the development of a new generation of immune-based therapeutics, which may eventually contribute to a curative intervention.
引用
收藏
页码：169 / 174
页数：6
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