Amyloid Hypothesis: The Emperor's New Clothes?

被引：8

作者：

Hoilund-Carlsen, Poul F. ^{[1
,2
]}

Barrio, Jorge R. ^{[3
]}

Werner, Tom J. ^{[4
]}

Newberg, Andrew ^{[5
,6
]}

Alavi, Abass ^{[4
]}

机构：

[1] Odense Univ Hosp, Dept Nucl Med, 29 Sdr Blvd, DK-5000 Odense C, Denmark

[2] Univ Southern Denmark, Dept Clin Res, Odense, Denmark

[3] David Geffen UCLA Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA USA

[4] Hosp Univ Penn, Dept Radiol, 3400 Spruce St, Philadelphia, PA 19104 USA

[5] Thomas Jefferson Univ, Dept Radiol, Philadelphia, PA 19107 USA

[6] Thomas Jefferson Univ, Dept Integrat Med & Nutr Sci, Marcus Inst Integrat Hlth, Philadelphia, PA 19107 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2020年 / 78卷 / 04期

关键词：

Alzheimer's disease; amyloid hypothesis; amyloid imaging; anti-amyloid therapeutic interventions; clinical usefulness; BETA; DISEASE;

D O I：

10.3233/JAD-200990

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The lengthy debate on the validity of the amyloid hypothesis and the usefulness of amyloid imaging and anti-amyloid therapeutic interventions in dementia continues unabated, even though none of them have been able to convince the medical world of their correctness and clinical value. There are huge financial interests associated with promoting both, but in spite of the large sums of money in their support, no effective anti-amyloid treatments or diagnostic use of amyloid imaging have emerged. There are solid scientific reasons that explain these negative results, and it is time to move forward to other promising options for the benefit of the patients.

引用

页码：1363 / 1366

页数：4

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