Photoacoustic resonance spectroscopy for biological tissue characterization

被引:43
|
作者
Gao, Fei [1 ]
Feng, Xiaohua [1 ]
Zheng, Yuanjin [1 ]
Ohl, Claus-Dieter [2 ]
机构
[1] Nanyang Technol Univ, Sch Elect & Elect Engn, Singapore 639798, Singapore
[2] Nanyang Technol Univ, Sch Phys & Math Sci, Singapore 639798, Singapore
基金
新加坡国家研究基金会;
关键词
photoacoustic; resonance; spectroscopy; characterization; MICROSCOPY; TOMOGRAPHY; RESOLUTION;
D O I
10.1117/1.JBO.19.6.067006
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
By "listening to photons," photoacoustics allows the probing of chromosomes in depth beyond the optical diffusion limit. Here we report the photoacoustic resonance effect induced by multiburst modulated laser illumination, which is theoretically modeled as a damped mass-string oscillator and a resistor-inductor-capacitor (RLC) circuit. Through sweeping the frequency of multiburst modulated laser, the photoacoustic resonance effect is observed experimentally on phantoms and porcine tissues. Experimental results demonstrate different spectra for each phantom and tissue sample to show significant potential for spectroscopic analysis, fusing optical absorption and mechanical vibration properties. Unique RLC circuit parameters are extracted to quantitatively characterize phantom and biological tissues. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE).
引用
收藏
页数:6
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