Facial and Hand Allotransplantation

被引：29

作者：

Pomahac, Bohdan ^{[1
]}

Gobble, Ryan M. ^{[1
]}

Schneeberger, Stefan ^{[2
,3
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Surg,Div Plast Surg, Boston, MA 02115 USA

[2] Med Univ Innsbruck, Dept Visceral Transplant & Thorac Surg, A-6020 Innsbruck, Austria

[3] Johns Hopkins Univ, Sch Med, Dept Plast & Reconstruct Surg, Baltimore, MD 21205 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2014年 / 4卷 / 03期

关键词：

COMPOSITE TISSUE ALLOTRANSPLANTATION; HUMAN FACE TRANSPLANTATION; WORLD EXPERIENCE; SENSORY RECOVERY; DOUBLE JAW; FREE FLAPS; REJECTION; ALLOGRAFT; RECIPIENT; OUTCOMES;

D O I：

10.1101/cshperspect.a015651

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Vascularized composite allotransplantation (VCA) is a novel therapeutic option for treatment of patients suffering from limb loss or severe facial disfigurement. To date, 72 hand and 19 facial transplantations have been performed worldwide. VCA in hand and facial transplantation is a complex procedure requiring a multidisciplinary team approach and extensive surgical planning. Despite good functional outcome, courses after hand and facial transplantation have been complicated by skin rejection. Long-term immunosuppression remains a necessity in VCA for allograft survival. To widen the scope of these quality-of-life-improving procedures, minimization of immunosuppression to limit risks and side effects is needed.

引用

页数：14

共 61 条

[1]

[Anonymous], 2012, DAILY MAIL ONLI 0228

[2] Technical Aspects of the Recipient Operation in Hand Transplantation [J].

Azari, Kodi K. ;

Imbriglia, Joseph E. ;

Goitz, Robert J. ;

Shores, Jaimie T. ;

Balk, Marshall L. ;

Brandacher, Gerald ;

Schneeberger, Stephan ;

Gorantla, Vijay ;

Lee, W. P. Andrew .

JOURNAL OF RECONSTRUCTIVE MICROSURGERY, 2012, 28 (01) :27-34

[3] Full Face Transplant The First Case Report [J].

Barret, Juan P. ;

Gavalda, Joan ;

Bueno, Javier ;

Nuvials, Xavier ;

Pont, Teresa ;

Masnou, Nuria ;

Colomina, Maria J. ;

Serracanta, Jordi ;

Arno, Anna ;

Huguet, Pere ;

Collado, Jose M. ;

Salamero, Pere ;

Moreno, Carlos ;

Deulofeu, Roser ;

Martinez-Ibanez, Vicenc .

ANNALS OF SURGERY, 2011, 254 (02) :252-256

[4]

BAUMEL JJ, 1974, ARCH OTOLARYNGOL, V99, P34

[5] Facial Animation With Free-Muscle Transfer Innervated by the Masseter Motor Nerve in Unilateral Facial Paralysis [J].

Bianchi, Bernardo ;

Copelli, Chiara ;

Ferrari, Silvano ;

Ferri, Andrea ;

Bailleul, Camille ;

Sesenna, Enrico .

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2010, 68 (07) :1524-1529

[6] The Innsbruck Hand Transplant Program: Update at 8 Years After the First Transplant [J].

Brandacher, G. ;

Ninkovic, M. ;

Piza-Katzer, H. ;

Gabl, M. ;

Hussl, H. ;

Rieger, M. ;

Schocke, M. ;

Egger, K. ;

Loescher, W. ;

Zelger, B. ;

Ninkovic, M. ;

Bonatti, H. ;

Boesmueller, C. ;

Mark, W. ;

Margreiter, R. ;

Schneeberger, S. .

TRANSPLANTATION PROCEEDINGS, 2009, 41 (02) :491-494

[7]

Brandacher G, 2007, HAND TRANSPLANTATION, P149

[8]

Brandacher G, 2012, EXPERT REV CLIN IMMU, V8, P673, DOI [10.1586/eci.12.54, 10.1586/ECI.12.54]

[9] Total Face, Double Jaw, and Tongue Transplant Simulation: A Cadaveric Study Using Computer-Assisted Techniques [J].

Brown, Emile N. ;

Dorafshar, Amir H. ;

Bojovic, Branko ;

Christy, Michael R. ;

Borsuk, Daniel E. ;

Kelley, T. Nicole ;

Shaffer, Cynthia K. ;

Rodriguez, Eduardo D. .

PLASTIC AND RECONSTRUCTIVE SURGERY, 2012, 130 (04) :815-823

[10] Craniofacial Principles in Face Transplantation [J].

Caterson, Edward J. ;

Diaz-Siso, J. Rodrigo ;

Shetye, Pradip ;

Junker, Johan P. E. ;

Bueno, Ericka M. ;

Soga, Shigeyoshi ;

Rybicki, Frank J. ;

Pomahac, Bohdan .

JOURNAL OF CRANIOFACIAL SURGERY, 2012, 23 (05) :1234-1238

← 1 2 3 4 5 6 7 →