Direct C-H Multifluoroarylation of Ethers through Hydrogen Atom Transfer Using Photoredox Catalysis

被引：27
|
作者：
Wang, Junlei [1 ]
Huang, Binbin [1 ]
Gao, Yuan [2 ]
Yang, Chao [1 ]
Xia, Wujiong [1 ]
机构：
[1] Harbin Inst Technol Shenzhen, State Key Lab Urban Water Resource & Environm, Shenzhen 518055, Peoples R China
[2] Yantai Univ, Sch Chem & Chem Engn, 30 Qingquan RD, Laishan Dist 264005, Yantai, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 11期
关键词：
BOND ACTIVATION; AROMATIC-SUBSTITUTION; ARYL CHLORIDES; FACILE ACCESS; F BOND; NICKEL; ELECTRON; FLUORINE; HYDRODEFLUORINATION; ALKYLATION;
D O I：
10.1021/acs.joc.9b00708
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A direct defluorinative multifluoroarylation of unactivated sp(3) C-H bonds through hydrogen atom transfer using photoredox catalysis has been developed. The C(sp(3))-C(sp(2)) couplings between C(sp(2))-F bonds and corresponding C(sp(3))-H bonds adjacent to heteroatoms proceeded smoothly to afford the desired products in moderate to good yields. Preliminary mechanistic investigations on this novel transformation revealed that the C-H cleavage process might be involved in the rate determining step.
引用
收藏
页码：6895 / 6903
页数：9
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