In vitro maturation and surrogacy in patients with vascular-type Ehlers-Danlos syndrome - A safe assisted reproductive technology approach

被引:5
作者
Bergeron, Marie-Eve [1 ,2 ]
Child, Tim [1 ]
Fatum, Muhammad [1 ]
机构
[1] Univ Oxford, Nuffield Dept Obstet & Gynaecol, Oxford Fertil Unit, Inst Reprod Sci, Oxford, England
[2] Univ Laval, Ctr Hosp Univ Quebec, Fac Med, Dept Obstet & Gynaecol, Quebec City, PQ G1V 4G2, Canada
关键词
Oocyte maturation; preimplantation genetic diagnosis; surrogacy; SYNDROME TYPE-IV; PREGNANCY; ARTERY;
D O I
10.3109/14647273.2014.903002
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Ehlers-Danlos syndrome (EDS) is an autosomal dominant connective tissue disorder with one of the highest maternal mortality rates of any condition. Patients with the vascular type of EDS are prone to spontaneous arterial and visceral ruptures. The occurrence of these severe and life-threatening complications is increased in pregnancy. Moreover, these patients carry a 50% risk of having an affected child. However, little is known about the risks of assisted conception treatments on these patients. We present the case of a 33-year-old woman suffering from EDS with a history of repeated ruptures of arterial aneurysms and a recently ruptured aneurysm of the splenic artery during her first intracytoplasmic sperm injection (ICSI) cycle who was then advised to undergo only unstimulated cycles. After a few natural ICSI cycles, the patient safely underwent two in vitro maturation cycles with pre-implantation genetic diagnosis in our unit. An unaffected blastocyst was transferred into a surrogate host. To our knowledge, this is the first case of EDS in assisted reproduction technologies including pre-implantation genetic diagnosis to be reported in the medical literature. This case has shown that unstimulated in vitro maturation and pre-implantation genetic diagnosis can safely be offered for vascular-type Ehlers-Danlos patients.
引用
收藏
页码:141 / 144
页数:4
相关论文
共 16 条
  • [1] Fatal bleeding following delivery:: A manifestation of the vascular type of Ehlers-Danlos' syndrome
    Bjorck, M.
    Pigg, M.
    Kragsterman, B.
    Bergqvist, D.
    [J]. GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 2007, 63 (03) : 173 - 175
  • [2] A rare cause of maternal death: liver and inferior vena cava rupture due to previously undiagnosed Ehlers-Danlos Syndrome type IV
    Combeer, E. L.
    Combeer, A. D.
    [J]. EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 2008, 25 (09) : 765 - 767
  • [3] Gdynia HJ, 2008, EUR J MED RES, V13, P229
  • [4] Ehlers-Danlos syndrome type IV
    Germain, Dominique P.
    [J]. ORPHANET JOURNAL OF RARE DISEASES, 2007, 2 (1)
  • [5] In vitro maturation or in vitro fertilization for women with polycystic ovaries? A case-control study of 194 treatment cycles
    Gremeau, Anne-Sophie
    Andreadis, Natasha
    Fatum, Muhammad
    Craig, Jo
    Turner, Karen
    Mcveigh, Enda
    Child, Tim
    [J]. FERTILITY AND STERILITY, 2012, 98 (02) : 355 - 360
  • [6] Ehlers Danlos Syndrome Type IV and pregnancy
    Hammond, Rebecca
    Oligbo, Nicholas
    [J]. ARCHIVES OF GYNECOLOGY AND OBSTETRICS, 2012, 285 (01) : 51 - 54
  • [7] Ehlers-Danlos syndrome in pregnancy
    Jaleel, S.
    Olah, K.
    [J]. JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2007, 27 (04) : 420 - 421
  • [8] Vascular Ehlers-Danlos syndrome and pregnancy: An obstetrical specific support
    Jamard, A.
    Le Hello, C.
    Simonet, T.
    Dreyfus, M.
    [J]. JOURNAL DE GYNECOLOGIE OBSTETRIQUE ET BIOLOGIE DE LA REPRODUCTION, 2012, 41 (07): : 676 - 678
  • [9] Kundu A K, 2006, J Assoc Physicians India, V54, P938
  • [10] Preimplantation genetic screening: does it help or hinder IVF treatment and what is the role of the embryo?
    Ly, Kim Dao
    Agarwal, Ashok
    Nagy, Zsolt Peter
    [J]. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2011, 28 (09) : 833 - 849