Expression of GLP-1R protein and its clinical role in intrahepatic cholangiocarcinoma tissues

被引：18

作者：

Chen, Ben-Dong ^{[1
]}

Zhao, Wen-Chao ^{[2
]}

Dong, Jian-Da ^{[3
]}

Sima, Hui ^{[4
]}

机构：

[1] NingXia Med Univ, Dept Hepatobiliary Surg, Gen Hosp, Ningxia 750004, Peoples R China

[2] Navy Hosp, Dept Hepatobiliary Surg, Beijing 100086, Peoples R China

[3] NingXia Med Univ, Dept Pathol, Basic Med Sci Sch, Ningxia 750004, Peoples R China

[4] Secong Militery Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Hepat Surg 5, Shanghai 200438, Peoples R China

来源：

MOLECULAR BIOLOGY REPORTS | 2014年 / 41卷 / 07期

关键词：

Intrahepatic cholangiocarcinoma; Western blot; GLP-1R; Tumor; GLUCAGON-LIKE PEPTIDE-1; RISK-FACTORS; EXTRAHEPATIC CHOLANGIOCARCINOMA; COLORECTAL-CANCER; UNITED-STATES; VIRUS-INFECTION; HEPATITIS; INSULIN; POPULATION; CELLS;

D O I：

10.1007/s11033-014-3302-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The study investigates the expression and clinical role of GLP-1R in intrahepatic cholangiocarcinoma (ICC) tissues. ICC tissue, tissue around tumour and normal liver tissue samples from 176 ICC patients were investigated for GLP-1R expression by immunohistochemistry and western blots. Expression levels were correlated to clinical variables and to the postoperative outcome. High GLP-1R expression levels were detected in tumor tissue samples. Kaplan-Meier method was used for survival analysis of patients follow-up data. Results showed that median survival time of patients with high GLP-1R positive expression in ICC tissue were 22 months. Median survival time of patients with low GLP-1R positive expression in ICC tissue were 19.8 months. There wasn't statistical difference (p = 0.332) between two groups. Immunohistochemistry semi-quantitative analysis showed that tissue differentiation is not prognostic risk factors. In patients with GLP-1R positive expression in ICC tissue, lymph node metastasis was important prognostic factors (p = 0.001). Although statistical analysis showed that GLP-1R can not be judged as a risk prognostic factors, GLP-1 might become a new target for therapy of ICC.

引用

页码：4313 / 4320

页数：8

共 44 条

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