Recent advances in inflammasome biology

被引：265

作者：

Place, David E. ^{[1
]}

Kanneganti, Thirumala-Devi ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Immunol, 332 N Lauderdale St, Memphis, TN 38105 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2018年 / 50卷

基金：

美国国家卫生研究院;

关键词：

NLRP3; INFLAMMASOME; PYRIN INFLAMMASOME; CELL-DEATH; CASPASE-1; AUTOPROTEOLYSIS; AIM2; ACTIVATION; INFECTION; NLRC4; PHOSPHORYLATION; PROTEIN;

D O I：

10.1016/j.coi.2017.10.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The inflammasome is a complex of proteins that through the activity of caspase-1 and the downstream substrates gasdermin D, IL-1 beta, and IL-18 execute an inflammatory form of cell death termed pyroptosis. Activation of this complex often involves the adaptor protein ASC and upstream sensors including NLRP1, NLRP3, NLRC4, AIM2, and pyrin, which are activated by different stimuli including infectious agents and changes in cell homeostasis. Here we discuss new regulatory mechanisms that have been identified for the canonical inflammasomes, the most recently identified NLRP9b inflammasome, and the new gasdermin family of proteins that mediate pyroptosis and other forms of regulated cell death.

引用

页码：32 / 38

页数：7

共 67 条

[1] Inflammatory Stimuli Regulate Caspase Substrate Profiles [J].

Agard, Nicholas J. ;

Maltby, David ;

Wells, James A. .

MOLECULAR & CELLULAR PROTEOMICS, 2010, 9 (05) :880-893

[2] Control of the innate immune response by the mevalonate pathway [J].

Akula, Murali K. ;

Shi, Man ;

Jiang, Zhaozhao ;

Foster, Celia E. ;

Miao, David ;

Li, Annie S. ;

Zhang, Xiaoman ;

Gavin, Ruth M. ;

Forde, Sorcha D. ;

Germain, Gail ;

Carpenter, Susan ;

Rosadini, Charles V. ;

Gritsman, Kira ;

Chae, Jae Jin ;

Hampton, Randolph ;

Silverman, Neal ;

Gravallese, Ellen M. ;

Kagan, Jonathan C. ;

Fitzgerald, Katherine A. ;

Kastner, Daniel L. ;

Golenbock, Douglas T. ;

Bergo, Martin O. ;

Wang, Donghai .

NATURE IMMUNOLOGY, 2016, 17 (08) :922-+

[3] Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression [J].

Bauernfeind, Franz G. ;

Horvath, Gabor ;

Stutz, Andrea ;

Alnemri, Emad S. ;

MacDonald, Kelly ;

Speert, David ;

Fernandes-Alnemri, Teresa ;

Wu, Jianghong ;

Monks, Brian G. ;

Fitzgerald, Katherine A. ;

Hornung, Veit ;

Latz, Eicke .

JOURNAL OF IMMUNOLOGY, 2009, 183 (02) :787-791

[4] Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin [J].

Boyden, ED ;

Dietrich, WF .

NATURE GENETICS, 2006, 38 (02) :240-244

[5] Intracellular Trafficking of Guanylate-Binding Proteins Is Regulated by Heterodimerization in a Hierarchical Manner [J].

Britzen-Laurent, Nathalie ;

Bauer, Michael ;

Berton, Valeria ;

Fischer, Nicole ;

Syguda, Adrian ;

Reipschlaeger, Simone ;

Naschberger, Elisabeth ;

Herrmann, Christian ;

Stuerzl, Michael .

PLOS ONE, 2010, 5 (12)

[6] Differential Requirement for Caspase-1 Autoproteolysis in Pathogen-Induced Cell Death and Cytokine Processing [J].

Broz, Petr ;

von Moltke, Jakob ;

Jones, Jonathan W. ;

Vance, Russell E. ;

Monack, Denise M. .

CELL HOST & MICROBE, 2010, 8 (06) :471-483

[7] Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in Mice [J].

Chae, Jae Jin ;

Cho, Young-Hun ;

Lee, Geun-Shik ;

Cheng, Jun ;

Liu, P. Paul ;

Feigenbaum, Lionel ;

Katz, Stephen I. ;

Kastner, Daniel L. .

IMMUNITY, 2011, 34 (05) :755-768

[8] Direct Proteolytic Cleavage of NLRP1B Is Necessary and Sufficient for Inflammasome Activation by Anthrax Lethal Factor [J].

Chavarria-Smith, Joseph ;

Vance, Russell E. .

PLOS PATHOGENS, 2013, 9 (06)

[9] Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner [J].

Conos, Stephanie A. ;

Chen, Kaiwen W. ;

De Nardo, Dominic ;

Hara, Hideki ;

Whitehead, Lachlan ;

Nunez, Gabriel ;

Masters, Seth L. ;

Murphy, James M. ;

Schroder, Kate ;

Vaux, David L. ;

Lawlor, Kate E. ;

Lindqvist, Lisa M. ;

Vince, James E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (06) :E961-E969

[10] AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity [J].

Di Micco, Antonia ;

Frera, Gianluca ;

Lugrin, Jerome ;

Jamilloux, Yvan ;

Hsu, Erh-Ting ;

Tardivel, Aubry ;

De Gassart, Aude ;

Zaffalon, Lea ;

Bujisic, Bojan ;

Siegert, Stefanie ;

Quadroni, Manfredo ;

Broz, Petr ;

Henry, Thomas ;

Hrycyna, Christine A. ;

Martinon, Fabio .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (32) :E4671-E4680

← 1 2 3 4 5 6 7 →