Curcumin as a preventive or therapeutic measure for chemotherapy and radiotherapy induced adverse reaction: A comprehensive review

被引：45

作者：

Akbari, Sadaf ^{[1
]}

Kariznavi, Elnaz ^{[2
]}

Jannati, Mahdi ^{[3
]}

Elyasi, Sepideh ^{[3
]}

Tayarani-Najaran, Zahra ^{[1
]}

机构：

[1] Mashhad Univ Med Sci, Med Toxicol Res Ctr, Mashhad, Razavi Khorasan, Iran

[2] Mashhad Univ Med Sci, Targeted Drug Delivery Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran

[3] Mashhad Univ Med Sci, Sch Pharm, Dept Clin Pharm, POB 9188617871, Mashhad, Razavi Khorasan, Iran

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2020年 / 145卷

关键词：

Curcumin; Turmeric; Cancer; Chemotherapy; Radiation; Adverse effect; CISPLATIN-INDUCED NEPHROTOXICITY; INDUCED PULMONARY-FIBROSIS; RADIATION DERMATITIS; MYOCARDIAL TOXICITY; OXIDATIVE STRESS; ORAL MUCOSITIS; KIDNEY; ANTIOXIDANT; CANCER; PHARMACOKINETICS;

D O I：

10.1016/j.fct.2020.111699

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Curcumin has attracted much attention for medicinal purposes in wide range of illnesses including cancer. In some studies, its efficacy is evaluated against chemotherapy and radiotherapy induced adverse reaction and also as adjuvant to cancer treatment. Here we have tried to present a comprehensive review on protective and therapeutic effect of curcumin against these side effects. Method: The data were collected by searching Scopus, PubMed, Medline, and Cochrane database systematic reviews, using key words "nephrotoxicity", "cardiotoxicity", "genotoxicity", "ototoxicity", "hepatotoxicity", "reproductive toxicity", "myelosuppression", "pulmonary toxicity", "radiotherapy induced side effect" with "turmeric" and "curcumin". Although curcumin has low bioavailability, it has shown brilliant profile on prevention and management of chemotherapy and radiotherapy induced adverse reactions, particularly based on in vitro and in vivo studies and limited number of human studies on radiotherapy adverse reactions. Antioxidant and anti-inflammatory properties of the curcumin are the main proposed mechanism of action for management and prevention of adverse reactions. One of the major points regarding the protective effect of curcumin is its wide tolerable therapeutic range of dose with minimal side effects. Furthermore, new nano-formulations help to improve the bioavailability, increase in efficacy and lower the adverse effects. In conclusion, based on the present knowledge, curcumin has significant supportive potential in patients receiving chemotherapy or radiotherapy and may be suggested as adjutant with cancer treatments. Further well-designed human studies are recommended.

引用

页数：13

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