In pursuit of carbohydrate-based HIV vaccines, Part 1: The total synthesis of hybrid-type gp120 fragments

被引：89

作者：

Mandal, M

Dudkin, VY

Geng, XD

Danishefsky, S

机构：

[1] Sloan Kettering Inst Canc Res, Bioorgan Chem Lab, New York, NY 10021 USA

[2] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 19期

关键词：

antigens; carbohydrates; glycoconjugates; glycopeptides; synthetic methods;

D O I：

10.1002/anie.200353625

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Key features in the successful synthesis of hybrid-type gp-120 fragments (see picture) include β-mannosylations to construct the core trisaccharide and a fragment-coupling strategy to install the upper" high-mannose domain."

引用

页码：2557 / 2561

页数：5

共 53 条

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