The EGAPP initiative: lessons learned

被引：37

作者：

Calonge, Ned ^{[1
]}

Klein, Roger D. ^{[2
]}

Berg, Alfred O. ^{[3
]}

Berg, Jonathan S. ^{[4
]}

Armstrong, Katrina ^{[5
]}

Botkin, Jeffrey ^{[6
]}

Campos-Outcalt, Doug ^{[7
]}

Djulbegovic, Benjamin ^{[8
,9
]}

Fisher, Nancy L. ^{[10
]}

Ganiats, Theodore G. ^{[11
,12
]}

Haddow, James E. ^{[13
]}

Hayes, Maxine ^{[14
]}

Janssens, A. Cecile J. W. ^{[15
]}

Kaye, Celia ^{[16
]}

Lyman, Donald O.

Offit, Kenneth ^{[17
]}

Pauker, Stephen G. ^{[18
]}

Phillips, Kathryn A. ^{[19
,20
]}

Piper, Margaret ^{[21
]}

Richards, Carolyn Sue ^{[22
]}

Scott, Joan A. ^{[23
]}

Strickland, Ora L. ^{[24
]}

Teutsch, Steven ^{[25
]}

Tunis, Sean R.

Veenstra, David L. ^{[26
,27
]}

Williams, Marc S. ^{[28
]}

Zallen, Doris T. ^{[29
]}

机构：

[1] Colorado Trust, Denver, CO 80202 USA

[2] Cleveland Clin Fdn, Cleveland, OH USA

[3] Univ Washington, Dept Family Med, Seattle, WA 98195 USA

[4] Univ N Carolina, Sch Med, Dept Genet, Chapel Hill, NC USA

[5] Univ Penn, Leonard Davis Inst Hlth Econ, Sch Med, Philadelphia, PA 19104 USA

[6] Univ Utah, Sch Med, Dept Pediat, Salt Lake City, UT 84112 USA

[7] Univ Arizona, Coll Med, Dept Family Community & Prevent Med, Phoenix, AZ USA

[8] Univ S Florida, Tampa, FL 33620 USA

[9] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA

[10] Ctr Medicare & Medicaid Serv, Seattle Reg Off, Seattle, WA USA

[11] Univ Calif San Diego, Sch Med, Dept Family & Prevent Med, La Jolla, CA 92093 USA

[12] Univ Calif San Diego, Hlth Serv Res Ctr, La Jolla, CA 92093 USA

[13] Brown Univ, Warren Alpert Med Sch, Dept Pathol & Lab Med, Providence, RI 02912 USA

[14] Washington State Dept Hlth, Tumwater, WA USA

[15] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA

[16] Univ Colorado, Sch Med, Boulder, CO 80309 USA

[17] Mem Sloan Kettering Canc Ctr, Clin Genet Serv, New York, NY USA

[18] Tufts Med Ctr, Dept Med, Div Clin Decis Making Informat & Telemed, Boston, MA USA

[19] Univ Calif San Francisco, Sch Pharm, Inst Hlth Policy Studies, San Francisco, CA 94143 USA

[20] Univ Calif San Francisco, UCSF Comprehens Canc Ctr, San Francisco, CA 94143 USA

[21] Kaiser Permanente, Ctr Hlth Res, Oakland, CA USA

[22] Oregon Hlth & Sci Univ, Dept Mol & Med Genet, Portland, OR 97201 USA

[23] Natl Coalit Hlth Profess Educ Genet, Washington, DC USA

[24] Florida Int Univ, Coll Nursing & Hlth Sci, Miami, FL 33199 USA

[25] Los Angeles Cty Dept Publ Hlth, Los Angeles, CA USA

[26] Univ Washington, Pharmaceut Outcomes Res & Policy Program, Seattle, WA 98195 USA

[27] Univ Washington, Inst Publ Hlth Genet, Seattle, WA 98195 USA

[28] Geisinger Hlth Syst, Genom Med Inst, Danville, PA USA

[29] Virginia Polytech Inst & State Univ, Dept Sci & Technol Soc, Blacksburg, VA 24061 USA

来源：

GENETICS IN MEDICINE | 2014年 / 16卷 / 03期

基金：

美国国家卫生研究院;

关键词：

evidence-based medicine; genetics; guideline development; public health genomics; systematic review methods; IMPROVE HEALTH OUTCOMES; WORKING-GROUP; RECOMMENDATIONS; CANCER; MORBIDITY; MORTALITY;

D O I：

10.1038/gim.2013.110

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The Evaluation of Genomic Applications in Practice and Prevention Working Group was first convened in 2005 to develop and test evidence-based methods for the evaluation of genomic tests in transition from research to clinical and public health practice. Over the ensuing years, the Working Group has met 26 times, publishing eight recommendation statements, two methods papers, and one outcomes paper, as well as planning and serving as technical experts on numerous associated systematic reviews. Evaluation of Genomic Applications in Practice and Prevention methods have evolved to address implications of the proliferation of genome-wide association studies and are currently expanding to face challenges expected from clinical implementation of whole-genome sequencing tests. In this article, we review the work of the Evaluation of Genomic Applications in Practice and Prevention Working Group over the first 8 years of its existence with an emphasis on lessons learned throughout the process. It is hoped that in addition to the published methods of the Working Group, the lessons we have learned along the way will be informative to others who are producers and consumers of evidence-based guidelines in the field of genomic medicine.

引用

页码：217 / 224

页数：8

共 17 条

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