Rifampin Enhances the Activity of Amphotericin B against Fusarium solani Species Complex and Aspergillus flavus Species Complex Isolates from Keratitis Patients

被引：0
|
作者：
He, Yi [1 ,2 ]
Zhou, Lutan [3 ]
Gao, Chuanwen [4 ]
Han, Lei [2 ,5 ]
Xu, Yan [2 ,6 ]
机构：
[1] Henan Prov Peoples Hosp, Cornea Serv, Henan Eye Inst & Henan Eye Hosp, Zhengzhou, Henan, Peoples R China
[2] Henan Prov Peoples Hosp, Dept Ophthalmol, Zhengzhou, Henan, Peoples R China
[3] Zhengzhou Railway Vocat & Tech Coll, Dept Optometry, Zhengzhou, Henan, Peoples R China
[4] Zhengzhou Second Hosp, Dept Ophthalmol, Zhengzhou, Henan, Peoples R China
[5] Henan Prov Peoples Hosp, Lab Ocular Microbiol, Henan Eye Inst & Henan Eye Hosp, Zhengzhou, Peoples R China
[6] Henan Prov Peoples Hosp, Lab Ocular Pharmacol, Henan Eye Inst & Henan Eye Hosp, Zhengzhou, Peoples R China
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 04期
基金：
中国国家自然科学基金;
关键词：
amphotericin B; Aspergillus flavus species complex; Fusarium solani species complex; rifampin; synergistic activity; fungal keratitis; IN-VITRO SUSCEPTIBILITY; FUNGAL KERATITIS; RESISTANT; THERAPY; ENDOPHTHALMITIS; POSACONAZOLE; PERSPECTIVES; INFECTIONS; PATHOGENS; NATAMYCIN;
D O I：
10.1128/AAC.02069-16
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The in vitro activities of amphotericin B in combination with rifampin were assessed against 95 ocular fungal isolates. The interactions between amphotericin B and rifampin at 4, 8, 16, and 32 mu g/ml were synergistic for 11.8%, 51.0%, 90.2%, and 94.1%, respectively, of Fusarium solani species complex isolates and for 13.6%, 45.5%, 93.2%, and 95.5%, respectively, of Aspergillus flavus species complex isolates. Antagonism was never observed for the amphotericin B-rifampin combinations.
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页数：5
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