Synthesis, characterisation and cytotoxicity of [(1,10-phenanthroline) (1R,2R,4R/1S, 2S,4S)-4-methyl-1,2-cyclohexanediamine) platinum(II)]2+ (PHEN-4-MeDACH)

被引：3

作者：

Garbutcheon-Singh, K. Benjamin ^{[1
]}

Galanski, Mathea S. ^{[2
]}

Keppler, Bernhard K. ^{[2
]}

Aldrich-Wright, Janice R. ^{[1
,3
]}

机构：

[1] Univ Western Sydney, Sch Sci & Hlth, Nanoscale Org & Dynam Grp, Locked Bag 1797, Penrith, NSW 2751, Australia

[2] Univ Vienna, Inst Inorgan Chem, A-1090 Vienna, Austria

[3] Univ Western Sydney, Sch Med, Penrith, NSW 2751, Australia

来源：

INORGANICA CHIMICA ACTA | 2016年 / 441卷

关键词：

(1R,2R,4R/1S, 2S,4S)-4-methyl-1,2-cyclohexanediamine; Cytotoxicity; Platinum; 1,10-Phenathroline; PLATINUM(II) COMPLEXES; ANTICANCER ACTIVITY; METALLOINTERCALATORS;

D O I：

10.1016/j.ica.2015.10.048

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We have synthesised, characterised and examined the cytotoxicity of [(1,10-phenanthroline) (1R,2R,4R/1S,2S,4S-4-methyl-cyclohexanediamine) platinum(II)](2+) (PHEN-4-MeDACH) in the L1210 cell line. The cytotoxicity of PHEN-4-MeDACH in the murine leukaemia (L12010) cell line was 1.8 +/- 0.00 mu M, comparable with that of [(1,10-phenanthroline)(1R, 2R-diaminocyclohexane) platinum (II)](2+) (1.5 +/- 0.14 mu M) but less cytotoxic than [(1,10-phenanthroline)(1S, 2S-diaminocyclohexane) platinum( II)](2+) (0.10 +/- 0.06 mu M) and cisplatin (0.43 +/- 0.06 mu M). +/- 2015 Elsevier B. V. All rights reserved.

引用

页码：152 / 156

页数：5

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