Terlipressin facilitates transport of septic patients treated with norepinephrine

被引:0
作者
Klein, Moti [1 ]
Weksler, Natan
Borer, Avraham
Koyfman, Leonid
Kesslin, Jerome
Gurman, Gabriel M.
机构
[1] Ben Gurion Univ Negev, Div Anesthesiol & Crit Care Med, Intens Care Unit, Soroka Univ Hosp,Dept Crit Care, IL-84101 Beer Sheva, Israel
[2] Ben Gurion Univ Negev, Div Internal Med, Intens Care Unit, Soroka Univ Hosp,Intens Dis Unit, IL-84101 Beer Sheva, Israel
[3] Ben Gurion Univ Negev, Fac Hlth Sci, IL-84101 Beer Sheva, Israel
[4] Rabin Med Ctr, Intens Care Unit, Petah Tiqwa, Israel
来源
ISRAEL MEDICAL ASSOCIATION JOURNAL | 2006年 / 8卷 / 10期
关键词
terlipressin; septic shock; norepinephrine; critically ill patient transport;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Transport of hemodynamic unstable septic patients for diagnostic or therapeutic interventions outside the intensive, care unit is complex but sometimes contributes to increasing the, chance of survival. Objectives: To report our experience with terlipressin treatment for facilitation of transport to distant facilities for diagnostic or therapeutic procedures in septic patients treated with norepinephrine. Methods: We conducted a retrospective analysis of the records of our ICU, identifying the patients with septic shock who required norepinephrine for hemodynamic support. Results: Terlipressin was given to 30 septic shock patients (15 females and 15 males) who were on high dose norepinephrine, (10 mu g/min or more) in order to facilitate their transport outside the ICU. The dose of terlipressin ranged from 1 to 4 mg, with a mean of 2.13 +/- 0.68 mg. The dose of norepinephrine needed to maintain systolic blood pressure above 100 mmHg decreased following terlipressin administration, from 21.9 +/- 10.4 mu g/min (range 5-52 mu g/min)to 1.0 +/- 1.95(range 0-10) (P < 0.001). No patients required norepinephrine dose adjustment during transport. No serious complications or overshoot in blood pressure values were observed following terlipressin administration. Acrocyanosis occurred only in eight patients receiving more than 1 mg of the drug. The overall mortality rate was 50%. Conclusions: Our data suggest that terlipressin is effective, in septic shock. Because it is long-acting and necessitates less titration it might be indicated for patient transportation.
引用
收藏
页码:691 / 693
页数:3
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