Synthesis and Antioxidant and Cytotoxic Activity of New Dihydroquercetin Derivatives

被引:4
作者
Knyazev, V. V. [1 ]
Rogovskii, V. S. [1 ]
Sveshnikova, E. D. [1 ]
Semeikin, A. V. [1 ]
Matyushin, A. I. [1 ]
Fedotcheva, T. A. [1 ]
Shimanovskii, N. L. [1 ]
Pozdeev, A. O. [2 ]
Koroteev, A. M. [2 ]
Koroteev, M. P. [2 ]
机构
[1] NI Pirogov Russian Natl Res Med Univ, 9A-1 Bolshaya Pirogovskaya St, Moscow 119435, Russia
[2] Moscow State Pedag Univ, Inst Biol & Chem, 6-2 Kibalchicha St, Moscow 129164, Russia
关键词
dihydroquercetin; 3-monoacylated dihydroquercetin derivatives; antioxidant activity; cytotoxic activity; taxifolin; ABTS test; HeLa cells; QUERCETIN;
D O I
10.1007/s11094-018-1791-8
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Aseries of new 3-monoacylated dihydroquercetin derivatives were synthesized and possessed antioxidant and cytotoxic activity with respect to HeLa tumor cells.
引用
收藏
页码:205 / 208
页数:4
相关论文
共 12 条
  • [1] Filimonov D.A., 2014, KHIM GETEROTSIKL, P483
  • [2] Kanadaswami C, 2005, IN VIVO, V19, P895
  • [3] Lakhanpal P, 2007, INTERNET J MED UPDAT, V2, P22
  • [4] Optimization of Ionic Liquid-Assisted Extraction of Biflavonoids from Selaginella doederleinii and Evaluation of Its Antioxidant and Antitumor Activity
    Li, Dan
    Qian, Yan
    Tian, Yu-Jia
    Yuan, Shi-Meng
    Wei, Wei
    Wang, Gang
    [J]. MOLECULES, 2017, 22 (04):
  • [5] Mironov A. N, 2012, HDB PRECLINICAL DRUG
  • [6] In Silico Study and Bioprospection of the Antibacterial and Antioxidant Effects of Flavone and Its Hydroxylated Derivatives
    Montenegro, Camila de Albuquerque
    Goncalves, Gregorio Fernandes
    de Oliveira Filho, Abrahao Alves
    Lira, Andressa Brito
    Mendes Cassiano, Thays Thyara
    Ramos de Lima, Natanael Teles
    Barbosa-Filho, Jose Maria
    de Fatima Formiga Melo Diniz, Margareth
    Freire Pessoa, Hilzeth Luna
    [J]. MOLECULES, 2017, 22 (06)
  • [7] Synthesis and Cytotoxic Activity of Dihydroquercetin Aryl Derivatives
    Nifantev, E. E.
    Koroteev, A. M.
    Pozdeev, A. O.
    Koroteev, M. P.
    Vasyanina, L. K.
    Kaziev, G. Z.
    Rogovskii, V. S.
    Knyazev, V. V.
    Shirokikh, K. E.
    Semeikin, A. V.
    Fedotcheva, T. A.
    Matyushin, A. I.
    Shimanovskii, N. L.
    [J]. PHARMACEUTICAL CHEMISTRY JOURNAL, 2015, 49 (02) : 78 - 81
  • [8] Nifantev E. E., 2014, DOKL AKAD NAUK, V459, P567
  • [9] Antioxidant activity applying an improved ABTS radical cation decolorization assay
    Re, R
    Pellegrini, N
    Proteggente, A
    Pannala, A
    Yang, M
    Rice-Evans, C
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 1999, 26 (9-10) : 1231 - 1237
  • [10] Rogovskii V. S., 2012, Eksperimental'naya i Klinicheskaya Farmakologiya, V75, P37