Cross-reactive anti-galactocerebroside antibodies and Mycoplasma pneumoniae infections in Guillain-Barre syndrome

被引：43
作者：
Ang, CW
Tio-Gillen, AP
Groen, J
Herbrink, P
Jacobs, BC
Van Koningsveld, R
Osterhaus, ADME
Van der Meché, FGA
van Doorn, PA
机构：
[1] Erasmus Med Ctr, Dept Med Microbiol & Infect Dis, NL-3015 GD Rotterdam, Netherlands
[2] Erasmus Med Ctr, Dept Neurol, NL-3015 GD Rotterdam, Netherlands
[3] Erasmus Med Ctr, Dept Immunol, NL-3015 GD Rotterdam, Netherlands
[4] Erasmus Med Ctr, Dept Virol, NL-3015 GD Rotterdam, Netherlands
[5] Diagnost Ctr SSDZ, Dept Immunol & Infect Dis, NL-2600 GA Delft, Netherlands
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2002年 / 130卷 / 1-2期
关键词：
molecular mimicry; neuropathy; Mycoplasma pneumoniae;
D O I：
10.1016/S0165-5728(02)00209-6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Anti-galactocerebroside (GalC) antibodies are reported to be present in GBS patients with preceding Mycoplasma pneumoniae (MP) infection. We investigated the presence of anti-GalC reactivity in serum of a large group of GBS patients using ELISA and compared this with healthy controls and individuals with an uncomplicated MP infection. Anti-GalC antibody reactivity was present in 12% of the GBS patients. Furthermore, anti-GalC antibodies were associated with NIP infections, a relatively mild form of the disease and demyelinating features. Anti-GalC antibodies cross-reacted with NIP antigen. In conclusion, anti-GalC antibodies in GBS patients may be induced by molecular mimicry with MP. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：179 / 183
页数：5
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