Facile synthesis of bis(arylmethylidene)cycloalkanones mediated by lithium perchlorate under solvent-free conditions

被引：35

作者：

Abaee, M. S. ^{[1
]}

Mojtahedi, M. M. ^{[1
]}

Sharifi, R. ^{[1
]}

Zahedi, M. M. ^{[1
]}

Abbasi, H. ^{[1
]}

Tabar-Heidar, K. ^{[1
]}

机构：

[1] Chem & Chem Engn Res Ctr Iran, Organ Chem Lab, Tehran, Iran

来源：

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY | 2006年 / 3卷 / 03期

关键词：

crossed aldol condensation; bis(arylmethylidene) cycloalkanones; lithium perchlorate; solvent-free;

D O I：

10.1007/BF03247222

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Lithium perchlorate-mediated double crossed aldol condensations of a variety of aromatic aldehydes with cycloalkanones at room temperature in the presence of ( trimethylsilyl) diethylamine and under solvent-free conditions are described. High to excellent yields of bis(arylmethylidene) cyclohexanones and bis( arylmethylidene) cyclopentanones are achieved within a few minutes in this facile one-pot procedure.

引用

页码：293 / 296

页数：4

共 25 条

[1] First highly efficient synthesis of bis(arylmethylidene)pyranones mediated by lithium perchlorate [J].

Abaee, MS ;

Mojtahedi, MM ;

Zahedi, MM ;

Bolourtchian, SM .

SYNTHETIC COMMUNICATIONS, 2006, 36 (02) :199-206

[2] An efficient and improved method for the synthesis of bis(arylmethylidene)thiopyranones [J].

Abaee, MS ;

Mojtahedi, MM ;

Zahedi, MM .

SYNLETT, 2005, (15) :2317-2320

[3] Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: Synthesis, biological evaluation, and molecular modeling [J].

Artico, M ;

Di Santo, R ;

Costi, R ;

Novellino, E ;

Greco, G ;

Massa, S ;

Tramontano, E ;

Marongiu, ME ;

De Montis, A ;

La Colla, P .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (21) :3948-3960

[4]

DELI J, 1984, PHARMAZIE, V39, P539

[5]

GANGADHARA KK, 1995, POLYMER, V36, P1903

[6] Synthesis, characterization, and structure-activity relationships of amidine-substituted (bis)benzylidene-cycloketone olefin isomers as potent and selective factor Xa inhibitors [J].

Guilford, WJ ;

Shaw, KJ ;

Dallas, JL ;

Koovakkat, S ;

Lee, W ;

Liang, A ;

Light, DR ;

McCarrick, MA ;

Whitlow, M ;

Ye, B ;

Morrissey, MM .

JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (26) :5415-5425

[7] AN ALDOL CONDENSATION EXPERIMENT USING A NUMBER OF ALDEHYDES AND KETONES [J].

HATHAWAY, BA .

JOURNAL OF CHEMICAL EDUCATION, 1987, 64 (04) :367-368

[8]

Hu XY, 2004, J CHEM RES, P684

[9] RuCl3 catalyses aldol condensations of aldehydes and ketones [J].

Iranpoor, N ;

Kazemi, F .

TETRAHEDRON, 1998, 54 (32) :9475-9480

[10] Aldol condensation of cycloalkanones with aromatic aldehydes catalysed with TiCl3(SO3CF3) [J].

Iranpoor, N ;

Zeynizadeh, B ;

Aghapour, A .

JOURNAL OF CHEMICAL RESEARCH-S, 1999, (09) :554-555

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