Evaluation of androgen receptor gene as a candidate gene in female androgenetic alopecia

被引:17
|
作者
El-Samahy, May H. [1 ]
Shaheen, Maha A. [1 ]
Saddik, Dina E. B. [1 ]
Fattah, Nermeen S. A. Abdel [1 ]
El-Sawi, Mohammad A. [2 ]
Mahran, Manal Z. [3 ]
Shehab, Abeer A. A. [3 ]
机构
[1] Ain Shams Univ, Fac Med, Dept Dermatol & Venereol, Cairo 11391, Egypt
[2] Ain Shams Univ, Fac Med, Dept Pediat, Genet Unit, Cairo 11391, Egypt
[3] Ain Shams Univ, Fac Med, Dept Clin Pathol, Cairo 11391, Egypt
关键词
MALE PATTERN BALDNESS; POLYMORPHISM; AR;
D O I
10.1111/j.1365-4632.2009.03991.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background Genetic polymorphisms of the androgen receptor (AR) gene have been studied in male androgenetic alopecia (AGA); however, little is known about gene polymorphism and female AGA. Aim To evaluate the AR gene as a candidate gene for female AGA. Methods Thirty premenopausal Egyptian female patients with AGA (mean age, 32.3 +/- 7 years) and 11 age- and sex-matched controls were included. All subjects underwent laboratory and pelvic ultrasound evaluation to exclude other precipitating cause(s) of hair loss. Scalp biopsy was taken and the AR gene was evaluated using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results According to Ludwig's classification, all patients had type II AGA. Statistical analysis showed no statistically significant difference in genotype (chi(2) = 5.513, P = 0.05) or allele frequency (chi(2) = 1.312, P = 0.05) between patients and controls. There was also no statistically significant difference between the genotype and allele frequency with disease duration. Conclusion In contrast with male AGA, no association was found between type II AGA in Egyptian women and the AR gene. Therefore, the genetic study of this gene does not serve as a biomarker for the identification of women with a predisposition to AGA.
引用
收藏
页码:584 / 587
页数:4
相关论文
共 50 条
  • [21] Differences of gene expression profiles related to androgenetic alopecia
    Oh, J. W.
    Sung, Y. K.
    Kim, J. C.
    Kim, M. K.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2008, 128 : S152 - S152
  • [22] Evaluation of the CTSL2 gene as a candidate gene for alopecia x in pomeranians and keeshonden
    Mausberg, E.-M.
    Droegemueller, C.
    Leeb, T.
    Dolf, G.
    Ruefenacht, S.
    Welle, M.
    ANIMAL BIOTECHNOLOGY, 2007, 18 (04) : 391 - 396
  • [23] Ornithine decarboxylase gene polymorphism and male androgenetic alopecia
    Garton, RA
    Sugarman, J
    Benushkova, K
    McMichael, AJ
    Setaluri, V
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2002, 119 (01) : 295 - 295
  • [24] Dermoscopic findings in female androgenetic alopecia
    Ramos, Lya Duarte
    Nahas Santili, Maria Candida
    Bezerra, Fabiane Castilho
    Maklouf Amorim Ruiz, Maria de Fatima
    Petri, Valeria
    Patriarca, Marisa Teresinha
    ANAIS BRASILEIROS DE DERMATOLOGIA, 2012, 87 (05) : 691 - 694
  • [25] Female androgenetic alopecia: A separate entity
    Norwood, OT
    Lehr, B
    DERMATOLOGIC SURGERY, 2000, 26 (07) : 679 - 682
  • [26] HORMONAL DIAGNOSTICS IN FEMALE ANDROGENETIC ALOPECIA
    MOLTZ, L
    GEBURTSHILFE UND FRAUENHEILKUNDE, 1988, 48 (04) : 203 - 214
  • [27] Association of a polymorphism in the ornithine decarboxylase gene with male androgenetic alopecia
    Garton, RA
    McMichael, AJ
    Sugarman, J
    Greer, K
    Setaluri, V
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2005, 52 (03) : 535 - 536
  • [28] Androgenetic alopecia in heterozygous carriers of a mutation in the human hairless gene
    Sprecher, E
    Shalata, A
    Dabhah, K
    Futerman, B
    Lin, S
    Szargel, R
    Bergman, R
    Friedman-Birnbaum, R
    Cohen, N
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2000, 42 (06) : 978 - 982
  • [30] TREATMENT OF FEMALE ANDROGENETIC ALOPECIA WITH CIMETIDINE
    ARAM, H
    INTERNATIONAL JOURNAL OF DERMATOLOGY, 1987, 26 (02) : 128 - 130