Unsafe SETs: histone lysine methyltransferases and cancer

被引：255
作者：
Schneider, R
Bannister, AJ
Kouzarides, T
机构：
[1] Wellcome Canc Res UK Inst, Cambridge CB2 1QR, England
[2] Dept Pathol, Cambridge CB2 1QR, England
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2002年 / 27卷 / 08期
关键词：
D O I：
10.1016/S0968-0004(02)02141-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Enzymes that covalently modify histones control many cellular processes by affecting gene expression. A new class of these enzymes is the histone lysine methyltransferase family, whose catalytic activity lies within a conserved domain, the SET domain. This article surveys the evidence for a connection between SET-domain-containing proteins and cancer. It proposes that deregulation of SET-domain function has an important role in carcinogenesis.
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页码：396 / 402
页数：7
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