Importance of metal complexes for development of potential leishmanicidal agents

被引：35
作者：
Tahghighi, Azar [1 ]
机构：
[1] Pasteur Inst Iran, BRC, MVRG, Tehran, Iran
来源：
JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2014年 / 770卷
关键词：
Leishmaniasis; Anti-leishmania; Metal complexes; Metallointercalators; Antiprotozoal; IN-VITRO; ANTILEISHMANIAL ACTIVITY; BIOLOGICAL-ACTIVITY; TROPICAL DISEASES; TRYPANOSOMA-CRUZI; KETOCONAZOLE COMPLEXES; PLATINUM(II) COMPLEXES; DNA INTERACTION; CHEMOTHERAPY; CLOTRIMAZOLE;
D O I：
10.1016/j.jorganchem.2014.08.007
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The occurrence of adverse effects and the development of resistance associated with the administration of conventional anti-leishmanial drugs explicate the urgent need for development of new leishmanicidal agents. The potential use of metal complexes as drugs against parasitic diseases has so far been very little explored. Leishmaniasis affects millions of people around the world with very limited therapeutic options for their treatment. This review focuses on the recent advances in the development of complex anti-leishmania agents. (C) 2014 Elsevier B. V. All rights reserved.
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收藏
页码：51 / 60
页数：10
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