The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets

被引:13
作者
Ebiloma, Godwin U. [1 ]
Ichoron, Nahandoo [2 ]
Siheri, Weam [3 ]
Watson, David G. [3 ]
Igoli, John O. [2 ,3 ]
De Koning, Harry P. [4 ]
机构
[1] Teesside Univ, Sch Hlth & Life Sci, Middlesbrough TS1 3BX, Cleveland, England
[2] Univ Agr, Dept Chem, Phytochem Res Grp, Makurdi 2373, Nigeria
[3] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G1 1XQ, Lanark, Scotland
[4] Univ Glasgow, Inst Infect Immun & Inflammat, Coll Med Vet & Life Sci, Glasgow G12 8TA, Lanark, Scotland
关键词
propolis; mode-of-action; Trypanosoma; Leishmania; Crithidia; kinetoplastid; natural compound; drug discovery; NEGLECTED TROPICAL DISEASES; NIGERIAN RED PROPOLIS; IN-VITRO; CHEMICAL-COMPOSITION; TRYPANOSOMA-CRUZI; BRAZILIAN PROPOLIS; HONEY-BEE; BIOLOGICAL-ACTIVITY; ANTILEISHMANIAL ACTIVITY; LEISHMANICIDAL ACTIVITY;
D O I
10.3390/molecules25215155
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The kinetoplastids are protozoa characterized by the presence of a distinctive organelle, called the kinetoplast, which contains a large amount of DNA (kinetoplast DNA (kDNA)) inside their single mitochondrion. Kinetoplastids of medical and veterinary importance include Trypanosoma spp. (the causative agents of human and animal African Trypanosomiasis and of Chagas disease) and Leishmania spp. (the causative agents of the various forms of leishmaniasis). These neglected diseases affect millions of people across the globe, but drug treatment is hampered by the challenges of toxicity and drug resistance, among others. Propolis (a natural product made by bees) and compounds isolated from it are now being investigated as novel treatments of kinetoplastid infections. The anti-kinetoplastid efficacy of propolis is probably a consequence of its reported activity against kinetoplastid parasites of bees. This article presents a review of the reported anti-kinetoplastid potential of propolis, highlighting its anti-kinetoplastid activity in vitro and in vivo regardless of geographical origin. The mode of action of propolis depends on the organism it is acting on and includes growth inhibition, immunomodulation, macrophage activation, perturbation of the cell membrane architecture, phospholipid disturbances, and mitochondrial targets. This gives ample scope for further investigations toward the rational development of sustainable anti-kinetoplastid drugs.
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页数:29
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