RLS3:: Fine-mapping of an autosomal dominant locus in a family with intrafamilial heterogeneity

被引：25
作者：
Liebetanz, K. M.
Winkelmann, J.
Trenkwalder, C.
Puetz, B.
Dichgans, M.
Gasser, T.
Mueller-Myhsok, B.
机构：
[1] Max Planck Inst Psychiat, Computat Genet Grp, RG Neurol Genet, D-80804 Munich, Germany
[2] Univ Gottingen, Dept Clin Neuropsychiat, D-3400 Gottingen, Germany
[3] Max Planck Inst Psychiat, RG Computat Genet, D-80804 Munich, Germany
[4] GSF, Natl Res Ctr, Munich, Germany
[5] Univ Munich, Klinikum Grosshadern, Dept Neurol, D-8000 Munich, Germany
[6] Univ Tubingen, Hertie Inst Clin Brain Res, Dept Neurodegenerat Dis, D-72074 Tubingen, Germany
来源：
NEUROLOGY | 2006年 / 67卷 / 02期
关键词：
RESTLESS LEGS SYNDROME; SUSCEPTIBILITY LOCUS;
D O I：
10.1212/01.wnl.0000224886.65213.b5
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A new locus for restless legs syndrome (RLS3) was identified on chromosome 9p24-22. The authors analyzed transmission disequilibrium tests (TDTs) and affecteds-only linkage analysis in one large family of Bavarian origin, taking into account age at onset. P values were 0.0054 for marker D9S1810 for TDT and 0.0009 for the affecteds-only linkage analysis, providing a confirmation of RLS3. This study narrows the region containing the autosomal dominant RLS3 locus to 11.1 cM (16.6 Mbp).
引用
收藏
页码：320 / 321
页数：2
相关论文
共 10 条
  • [1] Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology - A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health
    Allen, RP
    Picchietti, D
    Hening, WA
    Trenkwalder, C
    Walters, AS
    Montplaisi, J
    [J]. SLEEP MEDICINE, 2003, 4 (02) : 101 - 119
  • [2] Autosomal dominant restless legs syndrome maps on chromosome 14q
    Bonati, MT
    Ferini-Strambi, L
    Aridon, P
    Oldani, A
    Zucconi, M
    Casari, G
    [J]. BRAIN, 2003, 126 : 1485 - 1492
  • [3] Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p
    Chen, SH
    Ondo, WG
    Rao, SQ
    Li, L
    Chen, QY
    Wang, Q
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 74 (05) : 876 - 885
  • [4] COTTINGHAM RW, 1993, AM J HUM GENET, V53, P252
  • [5] Identification of a major susceptibility locus for restless legs syndrome on chromosome 12q
    Desautels, A
    Turecki, G
    Montplaisir, J
    Sequeira, A
    Verner, A
    Rouleau, GA
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (06) : 1266 - 1270
  • [6] Pedigree disequilibrium tests for multilocus haplotypes
    Dudbridge, F
    [J]. GENETIC EPIDEMIOLOGY, 2003, 25 (02) : 115 - 121
  • [7] Sobel E, 1996, AM J HUM GENET, V58, P1323
  • [8] WEEKS DE, 1990, AM J HUM GENET S, V47, P204
  • [9] Evidence for further genetic locus heterogeneity and confirmation of RLS-1 in restless legs syndrome
    Winkelmann, J
    Lichtner, P
    Pütz, B
    Trenkwalder, C
    Hauk, S
    Meitinger, T
    Strom, T
    Muller-Myhsok, B
    [J]. MOVEMENT DISORDERS, 2006, 21 (01) : 28 - 33
  • [10] Complex segregation analysis of restless legs syndrome provides evidence for an autosomal dominant mode of inheritance in early age at onset families
    Winkelmann, J
    Muller-Myhsok, B
    Wittchen, HU
    Hock, B
    Prager, M
    Pfister, H
    Strohle, A
    Eisensehr, I
    Dichgans, M
    Gasser, T
    Trenkwalder, C
    [J]. ANNALS OF NEUROLOGY, 2002, 52 (03) : 297 - 302
1