Synthesis of 8-[10B]-dihydroxyboryl-harmine, a potential agent for boron neutron capture therapy.

被引：0

作者：

Sintas, JA ^{[1
]}

Macareno, NJ ^{[1
]}

Vitale, AA ^{[1
]}

机构：

[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Organ, PROPLAME CONICET, RA-1428 Buenos Aires, DF, Argentina

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2000年 / 43卷 / 01期

关键词：

8-[B-10]- dihydroxyborylharmine; preparation and characterization; boron neutron capture therapy;

D O I：

暂无

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The preparation and spectral properties (MS, IR and NMR) of 8-[B-10]-dihydroxyborylharmine (III) are described. A general synthetic method was developed for an efficient production of boronated harmine; a potential agent for boron neutron capture therapy (BNCT) in brain.

引用

页码：97 / 101

页数：5

共 43 条

[41] SYNTHESIS OF RAC-1-(9-O-CARBORANYL)NONYL-2-METHYL-GLYCERO-3-PHOSPHOCHOLINE (B-ET-11-OME), A POTENTIAL BORON CARRIER FOR BORON NEUTRON-CAPTURE THERAPY (BNCT)
LEMMEN, P
WERNER, B
CHEMISTRY AND PHYSICS OF LIPIDS, 1992, 62 (02) : 185 - 191
[42] Synthesis of oxonium derivatives of the dodecahydro-closo-dodecaborate anion [B12H12]2-.: Tetramethylene oxonium derivative of [B12H12]2- as a convenient precursor for the synthesis of functional compounds for boron neutron capture therapy
Sivaev, IB
Semioshkin, AA
Brellochs, B
Sjöberg, S
Bregadze, VI
POLYHEDRON, 2000, 19 (06) : 627 - 632
[43] A UNIQUE INVIVO ASSESSMENT OF 4-[B-10]BORONO-L-PHENYLALANINE IN TUMOR-TISSUES FOR BORON NEUTRON-CAPTURE THERAPY OF MALIGNANT MELANOMAS USING POSITRON EMISSION TOMOGRAPHY AND 4-BORONO-2-[F-18]FLUORO-L-PHENYLALANINE
ISHIWATA, K
SHIONO, M
KUBOTA, K
YOSHINO, K
HATAZAWA, J
IDO, T
HONDA, C
ICHIHASHI, M
MISHIMA, Y
MELANOMA RESEARCH, 1992, 2 (03) : 171 - 179

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