Synthesis of 8-[10B]-dihydroxyboryl-harmine, a potential agent for boron neutron capture therapy.

被引：0
|
作者：
Sintas, JA [1 ]
Macareno, NJ [1 ]
Vitale, AA [1 ]
机构：
[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Organ, PROPLAME CONICET, RA-1428 Buenos Aires, DF, Argentina
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2000年 / 43卷 / 01期
关键词：
8-[B-10]- dihydroxyborylharmine; preparation and characterization; boron neutron capture therapy;
D O I：
暂无
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The preparation and spectral properties (MS, IR and NMR) of 8-[B-10]-dihydroxyborylharmine (III) are described. A general synthetic method was developed for an efficient production of boronated harmine; a potential agent for boron neutron capture therapy (BNCT) in brain.
引用
收藏
页码：97 / 101
页数：5
相关论文
共 43 条
  • [21] Synthesis and biological evaluation of closo-dodecaborate ibuprofen conjugate (DIC) as a new boron agent for neutron capture therapy
    Ishii, Satomu
    Nakamura, Hiroyuki
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2018, 865 : 178 - 182
  • [22] Synthesis of conjugates of L-fucose and ortho-carborane as potential agents for boron neutron capture therapy
    Basak, P
    Lowary, TL
    CANADIAN JOURNAL OF CHEMISTRY, 2002, 80 (08) : 943 - 948
  • [23] L-phenylalanine preloading reduces the 10B(n, α)7Li dose to the normal brain by inhibiting the uptake of boronophenylalanine in boron neutron capture therapy for brain tumours
    Watanabe, Tsubasa
    Tanaka, Hiroki
    Fukutani, Satoshi
    Suzuki, Minoru
    Hiraoka, Masahiro
    Ono, Koji
    CANCER LETTERS, 2016, 370 (01) : 27 - 32
  • [24] Boron Neutron Capture Therapy Study of10B Enriched Nanostructured Boron Carbide Against Cervical Cancer and Glioblastoma Cell Line
    Kaur, Manjot
    Singh, Paviter
    Meena, Ramovatar
    Nakagawa, Fumiko
    Suzuki, Minoru
    Nakamura, Hiroyuki
    Kumar, Akshay
    JOURNAL OF CLUSTER SCIENCE, 2021, 32 (01) : 221 - 225
  • [25] Boron uptake in normal melanocytes and melanoma cells and boron biodistribution study in mice bearing B16F10 melanoma for boron neutron capture therapy
    Fernanda Faião-Flores
    Paulo Rogério Pinto Coelho
    João Dias Toledo Arruda-Neto
    Maria Aparecida Pires Camillo
    Silvya Stuchi Maria-Engler
    Rose Eli Grassi Rici
    Jorge Eduardo Souza Sarkis
    Durvanei Augusto Maria
    Radiation and Environmental Biophysics, 2012, 51 : 319 - 329
  • [26] Boron uptake in normal melanocytes and melanoma cells and boron biodistribution study in mice bearing B16F10 melanoma for boron neutron capture therapy
    Faiao-Flores, Fernanda
    Pinto Coelho, Paulo Rogerio
    Toledo Arruda-Neto, Joao Dias
    Pires Camillo, Maria Aparecida
    Maria-Engler, Silvya Stuchi
    Grassi Rici, Rose Eli
    Souza Sarkis, Jorge Eduardo
    Maria, Durvanei Augusto
    RADIATION AND ENVIRONMENTAL BIOPHYSICS, 2012, 51 (03) : 319 - 329
  • [27] Applicability of the 2-nitroimidazole-sodium borocaptate-10B conjugate, TX-2060, as a 10B-carrier in boron neutron capture therapy
    Masunaga, SI
    Nagasawa, H
    Hiraoka, M
    Sakurai, Y
    Uto, Y
    Hori, H
    Nagata, K
    Suzuki, M
    Maruhashi, A
    Kinashi, Y
    Ono, K
    ANTICANCER RESEARCH, 2004, 24 (5A) : 2975 - 2983
  • [28] Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas
    CongXin Dai
    Feng Cai
    Kuo Chu Hwang
    YongMao Zhou
    ZiZhu Zhang
    XiaoHai Liu
    SiHai Ma
    YaKun Yang
    Yong Yao
    Ming Feng
    XinJie Bao
    GuiLin Li
    JunJi Wei
    YongHui Jiao
    ZhenQing Wei
    WenBin Ma
    RenZhi Wang
    Science China Life Sciences, 2013, 56 : 163 - 173
  • [29] Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas
    DAI CongXin
    CAI Feng
    HWANG Kuo Chu
    ZHOU YongMao
    ZHANG ZiZhu
    LIU XiaoHai
    MA SiHai
    YANG YaKun
    YAO Yong
    FENG Ming
    BAO XinJie
    LI GuiLin
    WEI JunJi
    JIAO YongHui
    WEI ZhenQing
    MA WenBin
    WANG RenZhi
    Science China(Life Sciences) , 2013, (02) : 163 - 173
  • [30] Folate receptor-mediated boron-10 containing carbon nanoparticles as potential delivery vehicles for boron neutron capture therapy of nonfunctional pituitary adenomas
    Dai CongXin
    Cai Feng
    Hwang Kuo Chu
    Zhou YongMao
    Zhang ZiZhu
    Liu XiaoHai
    Ma SiHai
    Yang YaKun
    Yao Yong
    Feng Ming
    Bao XinJie
    Li GuiLin
    Wei JunJi
    Jiao YongHui
    Wei ZhenQing
    Ma WenBin
    Wang RenZhi
    SCIENCE CHINA-LIFE SCIENCES, 2013, 56 (02) : 163 - 173
12345