Canadian β-lactamase-negative Haemophilus influenzae isolates showing decreased susceptibility toward ampicillin have significant penicillin binding protein 3 mutations

被引：16

作者：

Shuel, Michelle L. ^{[1
]}

Tsang, Raymond S. W. ^{[1
]}

机构：

[1] Publ Hlth Agcy Canada, Natl Microbiol Lab, Winnipeg, MB R3E 3R2, Canada

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2009年 / 63卷 / 04期

关键词：

BLNAR; BLPACR; H; influenzae; Canada; UNITED-STATES; RESISTANT; STRAINS; SURVEILLANCE; MENINGITIS; PREVALENCE; VACCINE;

D O I：

10.1016/j.diagmicrobio.2008.12.015

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Nineteen beta-lactamase-negative ampicillin-resistant (BLNAR:) and 2 beta-lactamase-positive amoxicillin-clavulanic acid-resistant Canadian Haemophilus influenzae strains were characterized. All 21 isolates were found to have the N526K mutations in their fts1 genes, and their ampicillin MIC50 values were 4-8 times that of beta-lactamase-negative ampicillin-susceptible strains. The difficulty in detection of BLNAR strains Was discussed. Crown Copyright (C) 2009 Published by Elsevier Inc. All rights reserved.

引用

页码：379 / 383

页数：5

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