1-[(6-Chloro-3-pyridyl)methyl]-N-(4-ethoxyphenyl)-3-phenyl-1H-pyrazole-5-carboxamide

被引:1
作者
Tang, Zheng [2 ]
Ding, Xiao-Liang [3 ]
Dong, Wen-Liang [4 ]
Zhao, Bao-Xiang [1 ]
机构
[1] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China
[2] Submarine Coll Navy, Qingdao 266071, Peoples R China
[3] Qingdao Univ, Coll Adv Profess Technol, Qingdao 266061, Peoples R China
[4] Shandong Univ Tradit Chinese Med, Sch Pharmaceut Sci, Jinan 250355, Peoples R China
来源
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2009年 / 65卷
关键词
PRELIMINARY BIOLOGICAL EVALUATION; LUNG-CANCER CELLS; POTENTIAL AGENTS; DERIVATIVES; DESIGN;
D O I
10.1107/S1600536809010290
中图分类号
O7 [晶体学];
学科分类号
0702 ; 070205 ; 0703 ; 080501 ;
摘要
In the title compound, C24H21ClN4O2, the pyrazole ring makes dihedral angles of 7.70 (11), 89.17 (11) and 40.68 (11)degrees with the phenyl, pyridine and ethoxyphenyl rings, respectively. There are some intramolecular C-H center dot center dot center dot O and C-H center dot center dot center dot pi bonds giving rigidity to the molecule, while weak intermolecular N-H center dot center dot center dot N and C-H center dot center dot center dot pi hydrogen bonds link the molecules into a two-dimensional structure.
引用
收藏
页码:O865 / U2937
页数:11
相关论文
共 8 条
[1]  
[Anonymous], SMART SAINT SADABS
[2]   1-(2-naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors.: Part 3:: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors [J].
Jia, ZZ ;
Wu, YH ;
Huang, WR ;
Zhang, PL ;
Song, YH ;
Woolfrey, J ;
Sinha, U ;
Arfsten, AE ;
Edwards, ST ;
Hutchaleelaha, A ;
Hollennbach, SJ ;
Lambing, JL ;
Scarborough, RM ;
Zhu, BY .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (05) :1229-1234
[3]   A short history of SHELX [J].
Sheldrick, George M. .
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2008, 64 :112-122
[4]   1-(6-Chloropyridin-3-ylmethyl)-3-phenyl-1H-pyrazole-5-carboxylic acid [J].
Tang, Zheng ;
Tang, Zheng ;
Ding, Xiao-Ling ;
Dong, Wen-Liang ;
Zhao, Bao-Xiang .
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2007, 63 :O3348-U4724
[5]   Design, synthesis, and preliminary biological evaluation of novel ethyl 1-(2′-hydroxy-3′-aroxypropyl)-3-aryl-1H-pyrazole-5-carboxylate [J].
Wei, Fang ;
Zhao, Bao-Xiang ;
Huang, Bin ;
Zhang, Lu ;
Sun, Chun-Hui ;
Dong, Wen-Liang ;
Shin, Dong-Soo ;
Miao, Jun-Ying .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (24) :6342-6347
[6]   Synthesis and structure-activity relationships of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide derivatives as potential agents against A549 lung cancer cells [J].
Xia, Yong ;
Dong, Zhi-Wu ;
Zhao, Bao-Xiang ;
Ge, Xiao ;
Meng, Ning ;
Shin, Dong-Soo ;
Miao, Jun-Ying .
BIOORGANIC & MEDICINAL CHEMISTRY, 2007, 15 (22) :6893-6899
[7]   Synthesis and preliminary biological evaluation of novel pyrazolo[1,5-a] pyrazin-4(5H)-one derivatives as potential agents against A549 lung cancer cells [J].
Zhang, Jin-Hua ;
Fan, Chuan-Dong ;
Zhao, Bao-Xiang ;
Shin, Dong-Soo ;
Dong, Wen-Liang ;
Xie, Yong-Sheng ;
Miao, Jun-Ying .
BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (24) :10165-10171
[8]   Synthesis and discovery of a novel pyrazole derivative as an inhibitor of apoptosis through modulating integrin β4, ROS, and p53 levels in vascular endothelial cells [J].
Zhao, Bao-Xiang ;
Zhang, Lu ;
Zhu, Xing-Shang ;
Wan, Mao-Sheng ;
Zhao, Jing ;
Zhang, Yun ;
Zhang, Shang-Li ;
Miao, Jun-Ying .
BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (09) :5171-5180