Engineered T cells for cancer therapy

被引：95
作者：
June, Carl H. [1 ,2 ]
Maus, Marcela V. [1 ,3 ]
Plesa, Gabriela [1 ]
Johnson, Laura A. [1 ,2 ]
Zhao, Yangbing [1 ,2 ]
Levine, Bruce L. [1 ,2 ]
Grupp, Stephan A. [1 ,4 ]
Porter, David L. [1 ,3 ]
机构：
[1] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA
[2] Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
[3] Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA 19104 USA
[4] Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA 19104 USA
来源：
CANCER IMMUNOLOGY IMMUNOTHERAPY | 2014年 / 63卷 / 09期
关键词：
Adoptive cell transfer; Gene transfer; Leukemia; Chimeric antigen receptor; 19th Danish Cancer Society Symposium; ADOPTIVE IMMUNOTHERAPY; ANTITUMOR-ACTIVITY; GENE-THERAPY; TOXICITY; REGRESSION; CD28; SPECIFICITY; PERSISTENCE; ACTIVATION; EXPRESSION;
D O I：
10.1007/s00262-014-1568-1
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
It is now well established that the immune system can control and eliminate cancer cells. Adoptive T cell transfer has the potential to overcome the significant limitations associated with vaccine-based strategies in patients who are often immune compromised. Application of the emerging discipline of synthetic biology to cancer, which combines elements of genetic engineering and molecular biology to create new biological structures with enhanced functionalities, is the subject of this focused research review.
引用
收藏
页码：969 / 975
页数：7
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