Metaplastic carcinoma of the breast: an immunohistochemical study

被引:42
作者
Altaf, Fadwa J. [1 ,2 ]
Mokhtar, Ghadeer A. [1 ,2 ,5 ]
Emam, Eman [1 ,2 ,3 ]
Bokhary, Rana Y. [1 ,2 ]
Bin Mahfouz, Najlaa [1 ,2 ]
Al Amoudi, Samia [1 ,2 ]
AL-Gaithy, Zuhoor K. [4 ]
机构
[1] King Abdulaziz Univ, Fac Med, Dept Pathol, Jeddah 21543, Saudi Arabia
[2] King Abdulaziz Univ, Fac Med, Dept Gen Surg, Jeddah 21543, Saudi Arabia
[3] Univ Alexandria, Fac Med, Dept Pathol, Alexandria, Egypt
[4] King Abdulaziz Univ, FRCSI, Dept Surg, Jeddah 21413, Saudi Arabia
[5] King Abdulaziz Univ, Fac Med, Dept Pathol, Jeddah 21589, Saudi Arabia
来源
DIAGNOSTIC PATHOLOGY | 2014年 / 9卷
关键词
Breast; Metaplastic carcinoma; Squamous cell carcinoma; Triple-negative carcinoma; INVASIVE DUCTAL CARCINOMA; BASAL-LIKE SUBTYPE; CLINICOPATHOLOGICAL FEATURES; CANCER; EXPRESSION; GRADE;
D O I
10.1186/1746-1596-9-139
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Background: Metaplastic breast carcinoma is a rare entity of breast cancer expressing epithelial and/or mesenchymal tissue within the same tumor. The aim of this study is to evaluate the clinicopathological features of metaplastic breast carcinoma and to confirm the triple negative, basal-like and/or luminal phenotype of this type of tumor by using immunohistochemical staining. Methods: Seven cases of MBC were evaluated for clinico-pathological features including follow up data. Cases were studied immunohistochemically by CK-Pan, Vimentin, ER, PR, HER2, basal markers (CK5/6, p63, EGFR, SMA and S-100), luminal cytokeratins (CK8, CK18 and CK19), markers for syncytial cells (beta-HCG and PLAP), as well as prognostic markers (p53, ki-67 and calretinin). Results: The mean age of the patients was 36 years. Three cases showed choriocarcinomatous features. All of our cases were negative for ER, PR and HER2. Six out of the 7 cases showed basal-like differentiation by demonstrating positivity with at least one of the basal/myoepithelial markers. Also 6 out of the 7 cases expressed luminal type cytokeratins (CK8, CK18 and/or CK19). P53 was positive in 3 cases, ki-67 was strongly expressed in only one case, while calretinin was expressed in 6 cases. Conclusion: Metaplastic breast carcinoma presents in our population at a younger age group than other international studies. All cases are categorized immunohistochemically under the triple negative group of breast cancer and 86% of them exhibited basal-like and luminal phenotype. Majority of cases developed local recurrence and distant metastasis in a relatively short period of time.
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页数:10
相关论文
共 40 条
[1]   Metaplastic carcinoma of the breast Clinical presentation, treatment results and prognostic factors [J].
Al Sayed, AD ;
El Weshi, AN ;
Tulbah, AM ;
Rahal, MM ;
Ezzat, AA .
ACTA ONCOLOGICA, 2006, 45 (02) :188-195
[2]  
[Anonymous], DIAGN PATHOL S1
[3]  
[Anonymous], DIAGN PATHOL
[4]   The prognoses of metaplastic breast cancer patients compared to those of triple-negative breast cancer patients [J].
Bae, Soo Youn ;
Lee, Se Kyung ;
Koo, Min Young ;
Hur, Sung Mo ;
Choi, Min-Young ;
Cho, Dong Hui ;
Kim, Sangmin ;
Choe, Jun-Ho ;
Lee, Jeong Eon ;
Kim, Jung-Han ;
Kim, Jee Soo ;
Nam, Seok Jin ;
Yang, Jung-Hyun .
BREAST CANCER RESEARCH AND TREATMENT, 2011, 126 (02) :471-478
[5]   Metaplastic breast cancer: clinical significance [J].
Beatty, J. David ;
Atwood, Mary ;
Tickman, Ronald ;
Reiner, Maureen .
AMERICAN JOURNAL OF SURGERY, 2006, 191 (05) :657-664
[6]   Primary angiosarcoma of the breast: a case report [J].
Bennani, Amal ;
Chbani, Layla ;
Lamchahab, Meryem ;
Wahbi, Mouhcine ;
Alaoui, Fatimazzahra Fdili ;
Badioui, Ikram ;
Melhouf, Moulay Abdelilah ;
Amarti, Affaf .
DIAGNOSTIC PATHOLOGY, 2013, 8
[7]   Metaplastic Breast Carcinomas and Their Relationship with Basal-Like Phenotype [J].
Cakir, Asli ;
Gonul, Ipek Isik ;
Uluoglu, Omer .
TURKISH JOURNAL OF PATHOLOGY, 2012, 28 (02) :134-141
[8]   Breast Carcinoma with Choriocarcinomatous Features [J].
Canbay, Emel ;
Bozkurt, Betul ;
Ergul, Gulusan ;
Agrali, Gul ;
Cengiz, Omer .
BREAST JOURNAL, 2010, 16 (02) :202-203
[9]   New Molecular Classifications of Breast Cancer [J].
Cianfrocca, Mary ;
Gradishar, William .
CA-A CANCER JOURNAL FOR CLINICIANS, 2009, 59 (05) :303-313
[10]   Molecular alterations in metaplastic breast carcinoma [J].
Cooper, Caroline Louise ;
Karim, Rooshdiya Z. ;
Selinger, Christina ;
Carmalt, Hugh ;
Lee, C. Soon ;
O'Toole, Sandra A. .
JOURNAL OF CLINICAL PATHOLOGY, 2013, 66 (06) :522-528