Adipose Tissue as an Endocrine Organ

被引：162

作者：

McGown, Christine ^{[1
]}

Birerdinc, Aybike ^{[1
,2
]}

Younossi, Zobair M. ^{[1
,2
,3
]}

机构：

[1] George Mason Univ, Coll Sci, Ctr Study Chron Metab Dis, Fairfax, VA 22030 USA

[2] Inova Hlth Syst, Betty & Guy Beatty Ctr Integrated Res, Falls Church, VA 22042 USA

[3] Inova Fairfax Hosp, Ctr Liver Dis, Dept Med, Falls Church, VA USA

来源：

CLINICS IN LIVER DISEASE | 2014年 / 18卷 / 01期

关键词：

Obesity; Adipose tissue; Endocrine; Hypoxia; Inflammation; Insulin resistance; FATTY LIVER-DISEASE; NECROSIS-FACTOR-ALPHA; MORBIDLY OBESE WOMEN; SMOOTH-MUSCLE-CELLS; INSULIN-RESISTANCE; GENE-EXPRESSION; TNF-ALPHA; NONALCOHOLIC STEATOHEPATITIS; ENDOTHELIAL-CELLS; HEPATIC STEATOSIS;

D O I：

10.1016/j.cld.2013.09.012

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Obesity is one of the most important health challenges faced by developed countries and is increasingly affecting adolescents and children. Obesity is also a considerable risk factor for the development of numerous other chronic diseases, such as insulin resistance, type 2 diabetes, heart disease and nonalcoholic fatty liver disease. The epidemic proportions of obesity and its numerous comorbidities are bringing into focus the highly complex and metabolically active adipose tissue. Adipose tissue is increasingly being considered as a functional endocrine organ. This article discusses the endocrine effects of adipose tissue during obesity and the systemic impact of this signaling.

引用

页码：41 / +

页数：20

共 94 条

[1] The association of adiponectin and low-grade inflammation with the course of metabolic syndrome [J].

Ahonen, T. M. ;

Saltevo, J. T. ;

Kautiainen, H. J. ;

Kumpusalo, E. A. ;

Vanhala, M. J. .

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2012, 22 (03) :285-291

[2]

Al Awadhi SA, 2012, INDIAN J MED RES, V135, P500

[3] Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity [J].

Arita, Y ;

Kihara, S ;

Ouchi, N ;

Takahashi, M ;

Maeda, K ;

Miyagawa, J ;

Hotta, K ;

Shimomura, I ;

Nakamura, T ;

Miyaoka, K ;

Kuriyama, H ;

Nishida, M ;

Yamashita, S ;

Okubo, K ;

Matsubara, K ;

Muraguchi, M ;

Ohmoto, Y ;

Funahashi, T ;

Matsuzawa, Y .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 257 (01) :79-83

[4] Plasma visfatin levels and gene expression in morbidly obese women with associated fatty liver disease [J].

Auguet, Teresa ;

Terra, Ximena ;

Porras, Jose Antonio ;

Maria Orellana-Gavalda, Josep ;

Martinez, Salome ;

Aguilar, Carmen ;

Lucas, Anna ;

Pellitero, Silvia ;

Hernandez, Merce ;

Del Castillo, Daniel ;

Richart, Cristobal .

CLINICAL BIOCHEMISTRY, 2013, 46 (03) :202-208

[5] Upregulation of Lipocalin 2 in Adipose Tissues of Severely Obese Women: Positive Relationship With Proinflammatory Cytokines [J].

Auguet, Teresa ;

Quintero, Yunuen ;

Terra, Ximena ;

Martinez, Salome ;

Lucas, Anna ;

Pellitero, Silvia ;

Aguilar, Carmen ;

Hernandez, Merce ;

del Castillo, Daniel ;

Richart, Cristobal .

OBESITY, 2011, 19 (12) :2295-2300

[6] Enhanced expression of ephrins and thrombospondins in the dermis of patients with early diffuse systemic sclerosis: potential contribution to perturbed angiogenesis and fibrosis [J].

Avouac, Jerome ;

Clemessy, Maud ;

Distler, Joerg H. ;

Gasc, Jean Marie ;

Ruiz, Barbara ;

Vacher-Lavenu, Marie Cecile ;

Wipff, Julien ;

Kahan, Andre ;

Boileau, Catherine ;

Corvol, Pierre ;

Allanore, Yannick .

RHEUMATOLOGY, 2011, 50 (08) :1494-1504

[7] Cocaine- and amphetamine-regulated transcript is expressed in adipocytes and regulate lipid- and glucose homeostasis [J].

Banke, E. ;

Riva, M. ;

Shcherbina, L. ;

Wierup, N. ;

Degerman, E. .

REGULATORY PEPTIDES, 2013, 182 :35-40

[8] Molecular signature of adipose tissue in patients with both Non-Alcoholic Fatty Liver Disease (NAFLD) and Polycystic Ovarian Syndrome (PCOS) [J].

Baranova, Ancha ;

Thuy Phuong Tran ;

Afendy, Arian ;

Wang, Lei ;

Shamsaddini, Amirhossein ;

Mehta, Rohini ;

Chandhoke, Vikas ;

Birerdinc, Aybike ;

Younossi, Zobair M. .

JOURNAL OF TRANSLATIONAL MEDICINE, 2013, 11

[9] Dynamic changes in lipid droplet-associated proteins in the "browning" of white adipose tissues [J].

Barneda, David ;

Frontini, Andrea ;

Cinti, Saverio ;

Christian, Mark .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2013, 1831 (05) :924-933

[10] A thrombospondin-1 antagonist of transforming growth factor-β activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II [J].

Belmadani, Souad ;

Bernal, Juan ;

Wei, Chih-Chang ;

Pallero, Manuel A. ;

Dell'Italia, Louis ;

Murphy-Ullrich, Joanne E. ;

Berecek, Kathleen H. .

AMERICAN JOURNAL OF PATHOLOGY, 2007, 171 (03) :777-789

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