Urinary fatty acid-binding protein 1: an early predictive biomarker of kidney injury

被引：127
作者：
Noiri, Eisei [1 ,2 ]
Doi, Kent [1 ,2 ]
Negishi, Kousuke [1 ,2 ]
Tanaka, Tamami [1 ,2 ]
Hamasaki, Yoshifumi [1 ,2 ]
Fujita, Toshiro [1 ,2 ]
Portilla, Didier [3 ,4 ]
Sugaya, Takeshi [5 ]
机构：
[1] Univ Tokyo, Univ Hosp, Dept Nephrol & Endocrinol, Tokyo 1138655, Japan
[2] Univ Tokyo, Univ Hosp, Dept Hemodialysis & Apheresis, Tokyo 1138655, Japan
[3] Univ Arkansas Med Sci, Div Nephrol, Dept Internal Med, Little Rock, AR 72205 USA
[4] Cent Arkansas Vet Healthcare Syst, Little Rock, AR USA
[5] CMIC Co Ltd, Tokyo, Japan
来源：
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | 2009年 / 296卷 / 04期
关键词：
acute kidney injury; chronic kidney disease; tubular injury; hypoxia; ACUTE-RENAL-FAILURE; UNITED-STATES; L-FABP; LIVER; SEPSIS; EXCRETION; DIAGNOSIS; DISEASE; EPIDEMIOLOGY; DYSFUNCTION;
D O I：
10.1152/ajprenal.90513.2008
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Noiri E, Doi K, Negishi K, Tanaka T, Hamasaki Y, Fujita T, Portilla D, Sugaya T. Urinary fatty acid-binding protein 1: an early predictive biomarker of kidney injury. Am J Physiol Renal Physiol 296: F669-F679, 2009. First published November 19, 2008; doi:10.1152/ajprenal.90513.2008.-In the development of novel therapeutic strategies for kidney disease, new renal biomarkers for early detection and accurate evaluation of renal injury are urgently required for both acute kidney injury (AKI) and chronic kidney disease (CKD). Fatty acid-binding protein 1 (FABP1) is expressed in renal proximal tubule cells and shed into urine in response to hypoxia caused by decreased peritubular capillary blood flow. To clarify the role of urinary FABP1 in kidney disease, we established human FABP1 transgenic mice and evaluated the responses of FABP1 to several AKI and CKD models. Moreover, there are accumulating clinical data that urinary FABP1 can detect human AKI earlier than serum creatinine and can distinguish the risk population for AKI. Investigation with "humanized" FABP1 transgenic mice and measurement of clinical samples allowed us to develop urinary FABP1 as a new renal biomarker. Further clinical studies are necessary to confirm the potential of urinary FABP1 for clinical application.
引用
收藏
页码：F669 / F679
页数：11
相关论文
共 61 条
[51]   Peeking into the black box: New biomarkers for acute kidney injury [J].
Thurman, J. M. ;
Parikh, C. R. .
KIDNEY INTERNATIONAL, 2008, 73 (04) :379-381
[52]   Acute renal failure in critically ill patients - A multinational, multicenter study [J].
Uchino, S ;
Kellum, JA ;
Bellomo, R ;
Doig, GS ;
Morimatsu, H ;
Morgera, S ;
Schetz, M ;
Tan, I ;
Bouman, C ;
Macedo, E ;
Gibney, N ;
Tolwani, A ;
Ronco, C .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 294 (07) :813-818
[53]   STRUCTURAL AND FUNCTIONAL FEATURES OF DIFFERENT TYPES OF CYTOPLASMIC FATTY ACID-BINDING PROTEINS [J].
VEERKAMP, JH ;
PEETERS, RA ;
MAATMAN, RGHJ .
BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1081 (01) :1-24
[54]   DETECTION, TISSUE DISTRIBUTION AND (SUB)CELLULAR LOCALIZATION OF FATTY ACID-BINDING PROTEIN TYPES [J].
VEERKAMP, JH ;
PAULUSSEN, RJA ;
PEETERS, RA ;
MAATMAN, RGHJ ;
VANMOERKERK, HTB ;
VANKUPPEVELT, THMSM .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 1990, 98 (1-2) :11-18
[55]   Association between increases in urinary neutrophil gelatinase-associated lipocalin and acute renal dysfunction after adult cardiac surgery [J].
Wagener, Gebhard ;
Jan, Michael ;
Kim, Mihwa ;
Mori, Kiyoshi ;
Barasch, Jonathan M. ;
Sladen, Robert N. ;
Lee, H. Thomas .
ANESTHESIOLOGY, 2006, 105 (03) :485-491
[56]   Lipotoxicity [J].
Weinberg, J. M. .
KIDNEY INTERNATIONAL, 2006, 70 (09) :1560-1566
[57]   Peritubular ischemia contributes more to tubular damage than proteinuria in immune-mediated glomerulonephritis [J].
Wong, Muh Geot ;
Suzuki, Yusuke ;
Tanifuji, Chiaki ;
Akiba, Hisaya ;
Okurnura, Ko ;
Sugaya, Takeshi ;
Yamamoto, Tokunori ;
Horikoshi, Satoshi ;
Tan, Si Yen ;
Pollock, Carol ;
Tomino, Yasuhiko .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2008, 19 (02) :290-297
[58]   The FDA critical path initiative and its influence on new drug development [J].
Woodcock, Janet ;
Woosley, Raymond .
ANNUAL REVIEW OF MEDICINE, 2008, 59 :1-12
[59]   8-HYDROXYADENINE AS THE INTERMEDIATE IN THE OXIDATION OF ADENINE TO 2,8-DIHYDROXYADENINE BY XANTHINE OXIDASE [J].
WYNGAARDEN, JB ;
DUNN, JT .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1957, 70 (01) :150-156
[60]   Intravital videomicroscopy of peritubular capillaries in renal ischemia [J].
Yamamoto, T ;
Tada, T ;
Brodsky, SV ;
Tanaka, H ;
Noiri, E ;
Kajiya, F ;
Goligorsky, MS .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2002, 282 (06) :F1150-F1155
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