Urinary fatty acid-binding protein 1: an early predictive biomarker of kidney injury

被引：125

作者：

Noiri, Eisei ^{[1
,2
]}

Doi, Kent ^{[1
,2
]}

Negishi, Kousuke ^{[1
,2
]}

Tanaka, Tamami ^{[1
,2
]}

Hamasaki, Yoshifumi ^{[1
,2
]}

Fujita, Toshiro ^{[1
,2
]}

Portilla, Didier ^{[3
,4
]}

Sugaya, Takeshi ^{[5
]}

机构：

[1] Univ Tokyo, Univ Hosp, Dept Nephrol & Endocrinol, Tokyo 1138655, Japan

[2] Univ Tokyo, Univ Hosp, Dept Hemodialysis & Apheresis, Tokyo 1138655, Japan

[3] Univ Arkansas Med Sci, Div Nephrol, Dept Internal Med, Little Rock, AR 72205 USA

[4] Cent Arkansas Vet Healthcare Syst, Little Rock, AR USA

[5] CMIC Co Ltd, Tokyo, Japan

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | 2009年 / 296卷 / 04期

关键词：

acute kidney injury; chronic kidney disease; tubular injury; hypoxia; ACUTE-RENAL-FAILURE; UNITED-STATES; L-FABP; LIVER; SEPSIS; EXCRETION; DIAGNOSIS; DISEASE; EPIDEMIOLOGY; DYSFUNCTION;

D O I：

10.1152/ajprenal.90513.2008

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Noiri E, Doi K, Negishi K, Tanaka T, Hamasaki Y, Fujita T, Portilla D, Sugaya T. Urinary fatty acid-binding protein 1: an early predictive biomarker of kidney injury. Am J Physiol Renal Physiol 296: F669-F679, 2009. First published November 19, 2008; doi:10.1152/ajprenal.90513.2008.-In the development of novel therapeutic strategies for kidney disease, new renal biomarkers for early detection and accurate evaluation of renal injury are urgently required for both acute kidney injury (AKI) and chronic kidney disease (CKD). Fatty acid-binding protein 1 (FABP1) is expressed in renal proximal tubule cells and shed into urine in response to hypoxia caused by decreased peritubular capillary blood flow. To clarify the role of urinary FABP1 in kidney disease, we established human FABP1 transgenic mice and evaluated the responses of FABP1 to several AKI and CKD models. Moreover, there are accumulating clinical data that urinary FABP1 can detect human AKI earlier than serum creatinine and can distinguish the risk population for AKI. Investigation with "humanized" FABP1 transgenic mice and measurement of clinical samples allowed us to develop urinary FABP1 as a new renal biomarker. Further clinical studies are necessary to confirm the potential of urinary FABP1 for clinical application.

引用

页码：F669 / F679

页数：11

共 61 条

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