Directed meta-metalation using alkali-metal-mediated zincation

被引：83
作者：
Armstrong, David R.
Clegg, William
Dale, Sophie H.
Hevia, Eva
Hogg, Lorna M.
Honeyman, Gordon W.
Mulvey, Robert E.
机构：
[1] Univ Strathclyde, Dept Pure & Appl Chem, Glasgow G1 1XL, Lanark, Scotland
[2] Newcastle Univ, Sch Nat Sci Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 23期
关键词：
anilides; deprotonation; metalation; sodium; zincation;
D O I：
10.1002/anie.200600720
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) Move over directed ortho-metalation, here comes directed meto-metalation. The unprecedented meto-zincation of two anilides by a synergic mixed sodium/zinc dialkyl-amide base is presented. The orientation of the deprotonation of the anilides is remarkably switched to the meta site using this heterometallic mixed-metal system. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
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收藏
页码：3775 / 3778
页数：4
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