Drugs for the Prevention and Treatment of Bronchopulmonary Dysplasia

被引：49
作者：
Mandell, Erica W. [1 ,2 ,3 ]
Kratimenos, Panagiotis [4 ]
Abman, Steven H. [1 ,2 ,5 ,6 ]
Steinhorn, Robin H. [4 ]
机构：
[1] Univ Colorado Denver, Sect Neonatol, Pediat Heart Lung Ctr, Anschutz Med Ctr, 12700 E 19th Ave,P14-4460A,MS8614, Aurora, CO 80045 USA
[2] Childrens Hosp Colorado, 12700 E 19th Ave,P14-4460A,MS8614, Aurora, CO 80045 USA
[3] Univ Colorado Denver, Anschutz Med Ctr, Sect Pulm Med, Aurora, CO 80045 USA
[4] Childrens Natl Med Ctr, Div Neonatol Neonatol & Hosp Based Specialties, 111 Michigan Ave NW, Washington, DC 20010 USA
[5] Univ Colorado Denver, Anschutz Med Ctr, Dept Pediat, Mail Stop B395,13123 East 16th Ave, Aurora, CO 80045 USA
[6] Childrens Hosp Colorado, Mail Stop B395,13123 East 16th Ave, Aurora, CO 80045 USA
来源：
CLINICS IN PERINATOLOGY | 2019年 / 46卷 / 02期
关键词：
Bronchopulmonary dysplasia; Chronic pulmonary insufficiency of prematurity; Pharmacology; Lungs; INHALED NITRIC-OXIDE; VITAMIN-A SUPPLEMENTATION; POSTNATAL SYSTEMIC CORTICOSTEROIDS; MESENCHYMAL STEM-CELLS; EARLY CAFFEINE THERAPY; CHRONIC LUNG-DISEASE; PRETERM INFANTS; PULMONARY-HYPERTENSION; RESPIRATORY OUTCOMES; PREMATURE NEWBORNS;
D O I：
10.1016/j.clp.2019.02.011
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Rates of bronchopulmonary dysplasia (BPD) are increasing. After preterm birth, there are important developmental periods in which neonates are more vulnerable to stressful events. These periods are opportunities for pharmacologic interventions. Many drugs remain inadequately tested and no new drugs have been approved in more than 25 years for BPD prevention or therapy. More progress is needed in defining appropriate end points based on the pathophysiology of BPD and post discharge chronic pulmonary insufficiency of prematurity and to develop effective new drugs. In addition, much work is needed to better define perinatal factors, early postnatal findings, and physiologic phenotypes or endotypes.
引用
收藏
页码：291 / +
页数：21
相关论文
共 127 条
  • [1] The Evolution of Bronchopulmonary Dysplasia after 50 Years
    Abman, Steven. H.
    Bancalari, Eduardo
    Jobe, Alan
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 195 (04) : 421 - 424
  • [2] Pediatric Pulmonary Hypertension Guidelines From the American Heart Association and American Thoracic Society
    Abman, Steven H.
    Hansmann, Georg
    Archer, Stephen L.
    Ivy, D. Dunbar
    Adatia, Ian
    Chung, Wendy K.
    Hanna, Brian D.
    Rosenzweig, Erika B.
    Raj, J. Usha
    Cornfield, David
    Stenmark, Kurt R.
    Steinhorn, Robin
    Theobaud, Bernard
    Fineman, Jeffrey R.
    Kuehne, Titus
    Feinstein, Jeffrey A.
    Friedberg, Mark K.
    Earing, Michael
    Barst, Robyn J.
    Keller, Roberta L.
    Kinsella, John P.
    Mullen, Mary
    Deterding, Robin
    Kulik, Thomas
    Mallory, George
    Humpl, Tilman
    Wessel, David L.
    [J]. CIRCULATION, 2015, 132 (21) : 2037 - 2099
  • [3] Implications of the U.S. Food and Drug Administration Warning against the Use of Sildenafil for the Treatment of Pediatric Pulmonary Hypertension
    Abman, Steven H.
    Kinsella, John P.
    Rosenzweig, Erika B.
    Krishnan, Usha
    Kulik, Thomas
    Mullen, Mary
    Wessel, David L.
    Steinhorn, Robin
    Adatia, Ian
    Hanna, Brian
    Feinstein, Jeffrey
    Fineman, Jeffrey
    Raj, Usha
    Humpl, Tilman
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2013, 187 (06) : 572 - 575
  • [4] Pulmonary NO synthase expression is attenuated in a fetal baboon model of chronic lung disease
    Afshar, S
    Gibson, LL
    Yuhanna, IS
    Sherman, TS
    Kerecman, JD
    Grubb, PH
    Yoder, BA
    McCurnin, DC
    Shaul, PW
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2003, 284 (05) : L749 - L758
  • [5] Two-Year Follow-Up Outcomes of Premature Infants Enrolled in the Phase I Trial of Mesenchymal Stem Cells Transplantation for Bronchopulmonary Dysplasia
    Ahn, So Yoon
    Chang, Yun Sil
    Kim, Ji Hye
    Sung, Se In
    Park, Won Soon
    [J]. JOURNAL OF PEDIATRICS, 2017, 185 : 49 - +
  • [6] TGF-β signaling is dynamically regulated during the alveolarization of rodent human lungs
    Alejandre-Alcazar, Miguel A.
    Michiels-Corsten, Matthias
    Vicencio, Alfin G.
    Reiss, Irwin
    Ryu, Julie
    de Krijger, Ronald R.
    Haddad, Gabriel G.
    Tibboel, Dick
    Seeger, Werner
    Eickelberg, Oliver
    Morty, Rory E.
    [J]. DEVELOPMENTAL DYNAMICS, 2008, 237 (01) : 259 - 269
  • [7] Early Caffeine and Weaning from Mechanical Ventilation in Preterm Infants: A Randomized, Placebo-Controlled Trial
    Amaro, Cynthia M.
    Bello, Jose A.
    Jain, Deepak
    Ramnath, Alexandra
    D'Ugard, Carmen
    Vanbuskirk, Silvia
    Bancalari, Eduardo
    Claure, Nelson
    [J]. JOURNAL OF PEDIATRICS, 2018, 196 : 52 - 57
  • [8] [Anonymous], 2012, Acog Practice Bulletin No. 130. Obstet Gynecol, V120, P964, DOI DOI 10.1097/AOG.0B013-3182723B1B
  • [9] Identification of gaps in the current knowledge on pulmonary hypertension in extremely preterm infants: A systematic review and meta-analysis
    Arjaans, Sanne
    Zwart, Elvira A. H.
    Ploegstra, Mark-Jan
    Bos, Arend F.
    Kooi, Elisabeth M. W.
    Hillege, Hans L.
    Berger, Rolf M. F.
    [J]. PAEDIATRIC AND PERINATAL EPIDEMIOLOGY, 2018, 32 (03) : 258 - 267
  • [10] Can We Prevent Bronchopulmonary Dysplasia?
    Aschner, Judy L.
    Bancalari, Eduardo H.
    McEvoy, Cindy T.
    [J]. JOURNAL OF PEDIATRICS, 2017, 189 : 26 - 30
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