Novel Avian-Origin Human Influenza A(H7N9) Can Be Transmitted Between Ferrets via Respiratory Droplets

被引：68

作者：

Xu, Lili ^{[1
,2
]}

Bao, Linlin ^{[1
,2
]}

Deng, Wei ^{[1
,2
]}

Dong, Libo ^{[3
]}

Zhu, Hua ^{[1
,2
]}

Chen, Ting ^{[1
,2
]}

Lv, Qi ^{[1
,2
]}

Li, Fengdi ^{[1
,2
]}

Yuan, Jing ^{[1
,2
]}

Xiang, Zhiguang ^{[1
,2
]}

Gao, Kai ^{[1
,2
]}

Xu, Yanfeng ^{[1
,2
]}

Huang, Lan ^{[1
,2
]}

Li, Yanhong ^{[1
,2
]}

Liu, Jiangning ^{[1
,2
]}

Yao, Yanfeng ^{[1
,2
]}

Yu, Pin ^{[1
,2
]}

Li, Xiyan ^{[3
]}

Huang, Weijuan ^{[3
]}

Zhao, Xiang ^{[3
]}

Lan, Yu ^{[3
]}

Guo, Junfeng ^{[3
]}

Yong, Weidong ^{[1
,2
]}

Wei, Qiang ^{[1
,2
]}

Chen, Honglin ^{[4
,5
]}

Zhang, Lianfeng ^{[1
,2
]}

Qin, Chuan ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing 100021, Peoples R China

[2] Peking Union Med Coll, Key Lab Human Dis Comparat Med, Minist Hlth, Comparat Med Ctr, Beijing 100021, Peoples R China

[3] Natl Inst Viral Dis Control & Prevent, Chinese Natl Influenza Ctr, State Key Lab Mol Virol & Genet Engn, Beijing, Peoples R China

[4] Univ Hong Kong, Dept Microbiol, State Key Lab Emerging Infect Dis, Pokfulam, Hong Kong, Peoples R China

[5] Univ Hong Kong, Res Ctr Infect & Immunol, Pokfulam, Hong Kong, Peoples R China

来源：

JOURNAL OF INFECTIOUS DISEASES | 2014年 / 209卷 / 04期

基金：

中国国家自然科学基金;

关键词：

H7N9 influenza virus; pathogenicity; transmissibility; animal models; VIRUS; TRANSMISSION;

D O I：

10.1093/infdis/jit474

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The outbreak of human infections caused by novel avian-origin influenza A(H7N9) in China since March 2013 underscores the need to better understand the pathogenicity and transmissibility of these viruses in mammals. In a ferret model, the pathogenicity of influenza A(H7N9) was found to be less than that of an influenza A(H5N1) strain but comparable to that of 2009 pandemic influenza A(H1N1), based on the clinical signs, mortality, virus dissemination, and results of histopathologic analyses. Influenza A(H7N9) could replicate in the upper and lower respiratory tract, the heart, the liver, and the olfactory bulb. It is worth noting that influenza A(H7N9) exhibited a low level of transmission between ferrets via respiratory droplets. There were 4 mutations in the virus isolated from the contact ferret: D678Y in the gene encoding PB2, R157K in the gene encoding hemagglutinin (H3 numbering), I109T in the gene encoding nucleoprotein, and T10I in the gene encoding neuraminidase. These data emphasized that avian-origin influenza A(H7N9) can be transmitted between mammals, highlighting its potential for human-to-human transmissibility.

引用

页码：551 / 556

页数：6

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